A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma
| Autor: | Aaron S. Farberg, Michael R. Migden, Nicholas Squittieri, Reinhard Dummer, C. William Hanke |
|---|---|
| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Spasm medicine.medical_specialty Skin Neoplasms Pyridines Vismodegib 610 Medicine & health Dysgeusia Sonidegib chemistry.chemical_compound Clinical Trials Phase II as Topic Internal medicine Humans Multicenter Studies as Topic Medicine Anilides Hedgehog Proteins Basal cell carcinoma Progression-free survival Dosing Adverse effect Randomized Controlled Trials as Topic business.industry Biphenyl Compounds 10177 Dermatology Clinic Alopecia General Medicine medicine.disease Progression-Free Survival Clinical trial chemistry Carcinoma Basal Cell medicine.symptom business Signal Transduction medicine.drug |
| Zdroj: | Journal of Drugs in Dermatology. 20:156-165 |
| ISSN: | 1545-9616 |
| DOI: | 10.36849/jdd.5657 |
| Popis: | Basal cell carcinoma (BCC) is the most common malignancy in fair-skinned populations. Most cases are successfully treated with surgery, but in advanced BCCmdash;including locally advanced BCC and metastatic BCCmdash;surgery is likely to result in substantial morbidity or unlikely to be effective. In those patients, the systemic Hedgehog inhibitors (HHIs) sonidegib and vismodegib are the only approved pharmacologic treatment option. Although a number of clinical studies highlight the similarities and differences between the two HHIs, no head-to-head clinical comparison is available. Results from the pivotal BOLT and ERIVANCE clinical studies for sonidegib and vismodegib, respectively, demonstrate similar efficacy measured by objective response rate, complete response rate, and histologic tumor subtype. Safety results for both studies are comparable with similar common adverse events reported for muscle spasms, alopecia, and dysgeusia. A notable difference between sonidegib and vismodegib is their respective pharmacokinetic profiles with sonidegib reaching peak concentration in plasma within 2ndash;4 hours of dosing and steady state in plasma achieved by week 17 of treatment, while vismodegib reaches peak plasma concentration approximately 2 days after a single dose and steady state within 21 days of repeated dosing. This review compares efficacy, safety, and pharmacokinetics of sonidegib and vismodegib based on published literature to date. J Drugs Dermatol. 2021;20(2):156-165. doi:10.36849/JDD.5657 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS. |
| Databáze: | OpenAIRE |
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