Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats
| Autor: | Šárka Jíchová, Janusz Sadowski, Zuzana Husková, Elzbieta Kompanowska-Jezierska, Libor Kopkan, John R. Falck, Herbert J. Kramer, Zdenka Vernerová, Petr Kujal, Luděk Červenka, Rami N. Reddy, Šárka Doleželová, Jan Neckář, John D. Imig |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Indoles Time Factors Physiology Blood Pressure 030204 cardiovascular system & hematology Epoxyeicosatrienoic acid Kidney Article Hypertension Malignant Renin-Angiotensin System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 8 11 14-Eicosatrienoic Acid Internal medicine Renin–angiotensin system Renin Internal Medicine medicine Cytochrome P-450 CYP1A1 Albuminuria Animals business.industry Angiotensin II Kidney metabolism Peptide Fragments Rats 030104 developmental biology Blood pressure Endocrinology medicine.anatomical_structure chemistry Renal blood flow medicine.symptom Angiotensin I Rats Transgenic Cardiology and Cardiovascular Medicine business |
| Popis: | OBJECTIVE We evaluated the therapeutic effectiveness of a new, orally active epoxyeicosatrienoic acid analog (EET-A) in rats with angiotensin II (ANG II)-dependent malignant hypertension. METHODS Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic. EET-A treatment was started either simultaneously with I3C induction process (early treatment) or 10 days later during established hypertension (late treatment). Blood pressure (BP) (radiotelemetry), indices of renal and cardiac injury, and plasma and kidney levels of the components of the renin-angiotensin system (RAS) were determined. RESULTS In I3C-induced hypertensive rats, early EET-A treatment attenuated BP increase (to 175 ± 3 versus 193 ± 4 mmHg, P |
| Databáze: | OpenAIRE |
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