All-trans-retinoic acid represses chemokine expression in adipocytes and adipose tissue by inhibiting NF-κB signaling

Autor: Lauriane Bonnet, Charlène Couturier, Jean-François Landrier, Julien Astier, Julie Dalifard, Franck Tourniaire, Esma Karkeni
Přispěvatelé: Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Lipopolysaccharides
Male
0301 basic medicine
Chemokine
obesity
Panniculitis
Lipopolysaccharide
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Retinoic acid
Adipose tissue
tissu adipeux
nutrition préventive
Biochemistry
NF-κB
Mice
chemistry.chemical_compound
0302 clinical medicine
Adipocyte
Adipocytes
ATRA
Nutrition and Dietetics
biology
monocyte-derived macrophages
NF-kappa B
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
adipose tissue
obésité
lipocytes
réaction inflammatoire
medicine.symptom
Chemokines
acide rétinoïque
Signal Transduction
chimiokine
medicine.medical_specialty
Tretinoin
030209 endocrinology & metabolism
Inflammation
macrophage
adipocyte
Proinflammatory cytokine
03 medical and health sciences
vitamin a acid
3T3-L1 Cells
Internal medicine
medicine
Animals
Humans
Molecular Biology
Macrophages
Inflammatory response
Macrophage migration
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
chemistry
Dietary Supplements
biology.protein
Transcriptome
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: Journal of Nutritional Biochemistry
Journal of Nutritional Biochemistry, Elsevier, 2017, 42, pp.101-107. ⟨10.1016/j.jnutbio.2017.01.004⟩
Journal of Nutritional Biochemistry, 2017, 42, pp.101-107. ⟨10.1016/j.jnutbio.2017.01.004⟩
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2017.01.004⟩
Popis: An effect of the Vitamin A metabolite all-trans-retinoic acid (ATRA) on body weight regulation and adiposity has been described, but little is known about its impact on obesity-associated inflammation. Our objective was to evaluate the overall impact of this metabolite on inflammatory response in human and mouse adipocytes, using high-throughput methods, and to confirm its effects in a mouse model. ATRA (2 μM for 24 h) down-regulated the mRNA expression of 17 chemokines in human adipocytes, and limited macrophage migration in a TNFα-conditioned 3 T3-L1 adipocyte medium (73.7%, P
Databáze: OpenAIRE
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