Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: task and statistical threshold effects on language lateralization

Autor: M. Elizabeth Meyerand, Peng Yin, Aaron S. Field, Ryan Holdsworth, Brittany M. Young, Chad H. Moritz, Veena A. Nair, Joshua Pankratz, Andrew C. Radtke, John S. Kuo, Tanvi N. Nadkarni, Mustafa K. Baskaya, Vivek Prabhakaran, Matthew J. Andreoli, Bornali Kundu
Rok vydání: 2014
Předmět:
Adult
Male
Pathology
medicine.medical_specialty
Lateralization index (LI)
Cognitive Neuroscience
Brain tumor
Audiology
lcsh:Computer applications to medicine. Medical informatics
Brain mapping
Surgical planning
lcsh:RC346-429
Lateralization of brain function
Functional Laterality
Task (project management)
Task-specific
Preoperative Care
medicine
Image Processing
Computer-Assisted
Humans
Radiology
Nuclear Medicine and imaging
LI
lateralization index
lcsh:Neurology. Diseases of the nervous system
Language
Brain Mapping
medicine.diagnostic_test
Brain Neoplasms
fMRI
Magnetic resonance imaging
Regular Article
Middle Aged
medicine.disease
Magnetic Resonance Imaging
LWG
letter-word generation
Cerebrovascular Disorders
Neurology
Thresholding
lcsh:R858-859.7
Female
AWG
antonym-word generation
Neurology (clinical)
Threshold model
Functional magnetic resonance imaging
Psychology
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 7, Iss C, Pp 415-423 (2015)
ISSN: 2213-1582
Popis: Background and purpose Functional magnetic resonance imaging (fMRI) is a non-invasive pre-surgical tool used to assess localization and lateralization of language function in brain tumor and vascular lesion patients in order to guide neurosurgeons as they devise a surgical approach to treat these lesions. We investigated the effect of varying the statistical thresholds as well as the type of language tasks on functional activation patterns and language lateralization. We hypothesized that language lateralization indices (LIs) would be threshold- and task-dependent. Materials and methods Imaging data were collected from brain tumor patients (n = 67, average age 48 years) and vascular lesion patients (n = 25, average age 43 years) who received pre-operative fMRI scanning. Both patient groups performed expressive (antonym and/or letter-word generation) and receptive (tumor patients performed text-reading; vascular lesion patients performed text-listening) language tasks. A control group (n = 25, average age 45 years) performed the letter-word generation task. Results Brain tumor patients showed left-lateralization during the antonym-word generation and text-reading tasks at high threshold values and bilateral activation during the letter-word generation task, irrespective of the threshold values. Vascular lesion patients showed left-lateralization during the antonym and letter-word generation, and text-listening tasks at high threshold values. Conclusion Our results suggest that the type of task and the applied statistical threshold influence LI and that the threshold effects on LI may be task-specific. Thus identifying critical functional regions and computing LIs should be conducted on an individual subject basis, using a continuum of threshold values with different tasks to provide the most accurate information for surgical planning to minimize post-operative language deficits.
Highlights • FMRI calculation of language lateralization is valuable for pre-surgical planning. • Both applied statistical thresholds and task specificity affect lateralization index. • A continuum of threshold values provides a dynamic range for presurgical planning. • Reorganization of language function is dependent on brain pathology. • Identification of critical language areas will optimize lesion resection (e.g. tumor).
Databáze: OpenAIRE
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