Clinical application of sperm-oocyte interaction tests in in vitro fertilization–embryo transfer and intracytoplasmic sperm injection programs
| Autor: | De Yi Liu, Claire Garrett, H.W. Gordon Baker |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Infertility endocrine system medicine.medical_specialty medicine.medical_treatment Acrosome reaction Semen Fertilization in Vitro Semen analysis Biology Intracytoplasmic sperm injection Andrology medicine Humans Sperm Injections Intracytoplasmic reproductive and urinary physiology Sperm-Ovum Interactions Gynecology In vitro fertilisation medicine.diagnostic_test urogenital system Obstetrics and Gynecology Embryo Transfer medicine.disease Sperm Reproductive Medicine Female |
| Zdroj: | Fertility and Sterility. 82:1251-1263 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2003.10.057 |
| Popis: | Objective To review the clinical value of sperm-oocyte interaction tests for the diagnosis and management of infertility by standard IVF or intracytoplasmic sperm injection (ICSI). Design Review of recent publications on relationships among sperm-oocyte interaction tests, sperm characteristics, and results of IVF and determination of frequency of defective sperm-oocyte interaction in infertile men. Main outcome measure(s) Fertilization rates with IVF, sperm characteristics, sperm–zona pellucida (ZP) binding, ZP-induced acrosome reaction (AR), and sperm-ZP penetration. Result(s) Sperm defects associated with low sperm-ZP binding or impaired ZP-induced AR and sperm-ZP penetration are the major causes of failure of fertilization when all or most oocytes from a couple do not fertilize in standard IVF. There is a high frequency of defective sperm-ZP interaction in men with oligozoospermia ( 6 /mL) and severe teratozoospermia (strict normal sperm morphology ≤5%). Sperm morphology correlates with sperm-ZP binding, and sperm concentration correlates with ZP-induced AR in infertile men with sperm concentrations >20 × 10 6 /mL. Defective ZP-induced AR may cause infertility in up to 25% men with idiopathic infertility. These patients require ICSI despite the normal standard semen analyses. Conclusion(s) Sperm-oocyte interaction tests are useful for diagnosis of subtle sperm defects that cause infertility in men without severe abnormalities of semen analysis. Pre-IVF diagnosis of these sperm defects will assist in the clinical assignment of patients to treatment with either standard IVF or ICSI. |
| Databáze: | OpenAIRE |
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