Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid
| Autor: | Torben F. Ørntoft, Karin Birkenkamp-Demtröder, Päivi Laiho, Lauri A. Aaltonen, Søren Laurberg, Sanne H. Olesen, Flemming Brandt Sørensen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Colorectal cancer Cecal Neoplasms Adenocarcinoma Caecum Cytokeratin Intestinal mucosa Gene expression Biomarkers Tumor medicine Humans RNA Neoplasm Intestinal Mucosa Aged Oligonucleotide Array Sequence Analysis Colon Cancer biology Rectal Neoplasms Gene Expression Profiling Gastroenterology Middle Aged biology.organism_classification medicine.disease digestive system diseases Neoplasm Proteins Gene Expression Regulation Neoplastic Gene expression profiling Sigmoid Neoplasms Real-time polymerase chain reaction Microsatellite Repeats |
| Zdroj: | Birkenkamp-Demtröder, K, Olesen, S, Sørensen, F B, Laurberg, S, Laiho, P, Aaltonen, LA & Ørntoft, T F 2005, ' Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid ', Gut, vol. 54, no. 3 . Aarhus University |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.2003.036848 |
| Popis: | Background and aims: There are epidemiological, morphological, and molecular differences between normal mucosa as well as between adenocarcinomas of the right and left side of the large bowel. The aim of this study was to investigate differences in gene expression. Methods: Oligonucleotide microarrays (GeneChip) were used to compare gene expression in 45 single samples from normal mucosa and sporadic colorectal carcinomas (Dukes’ B and C) of the caecum compared with the sigmoid and rectosigmoid. Findings were validated by real time polymerase chain reaction. Results: Fifty eight genes were found to be differentially expressed between the normal mucosa of the caecum and the sigmoid and rectosigmoid (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|