Consequences of Preservative Uptake and Release by Contact Lenses
| Autor: | Carol A. Morris, Andrew Luk, Melanie George, Victoria Rogers, Jing Ni, Inna Maltseva, Kathleen Khong, Charles B Derringer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Preservative Hydrochloride medicine.medical_treatment Biguanides law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anti-Infective Agents law medicine Humans skin and connective tissue diseases Chromatography Bacteria Preservatives Pharmaceutical nutritional and metabolic diseases Contact Lenses Hydrophilic Lens (optics) Contact lens Ophthalmology Artificial tears Methacrylic acid chemistry Self-healing hydrogels 030221 ophthalmology & optometry Contact Lens Solutions Antibacterial activity 030217 neurology & neurosurgery |
| Zdroj: | Eye & Contact Lens: Science & Clinical Practice. 44:S247-S255 |
| ISSN: | 1542-2321 |
| DOI: | 10.1097/icl.0000000000000480 |
| Popis: | Objectives To assess contact lens preservative uptake and release from multipurpose solutions (MPS) and subsequent acquisition of lens antibacterial activity. Methods Kinetics of uptake and release of poly (hexamethylene biguanide hydrochloride) (PHMB) or polyquaternium-1 (PQ-1) from various contact lenses were studied initially with the pure compounds and then after soaking in MPS containing these compounds. Lenses soaked in MPS were tested for antibacterial activity. Results Only lenses with a negatively charged component absorbed these preservatives. For lenses containing methacrylic acid (MA), uptake of PHMB from preservative-only solution was fast, yet little was released, in contrast to its rapid release from lenses containing other anionic groups. This trend persisted with PHMB-containing MPS. PQ-1 from preservative-only solution was only absorbed by lenses containing MA and was released from MA-containing hydrogels, but not significantly from an MA-containing silicone hydrogel. Lens uptake of PQ-1 was much lower from MPS and release was essentially undetectable from all lenses evaluated. Antibacterial lens activity was acquired by lenses containing MA after an overnight soak in MPS containing PQ-1, and for balafilcon A and omafilcon A after 5 exchanges in PHMB-containing MPS. Acquired activity was maintained during cycling between artificial tear protein solution and MPS. Conclusions Lens preservative uptake and its subsequent release are dependent on lens chemistry, preservative nature, and other MPS components. A few lens/solution combinations acquired antibacterial activity after one or more overnight soaks in MPS, depending on the nature of the anionic lens component and the preservative. Uncharged lenses did not acquire antibacterial activity. |
| Databáze: | OpenAIRE |
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