Synthesis and Biological Evaluation of 4′-Substituted Kaempfer-3-ols
| Autor: | Ariel T Tarr, Peyton R Sayasith, Lin Lin, Deborah A. Lannigan, Yu Li, George A. O'Doherty, Sugyeom Kim, Eric B Wright, Sharia Yasmin |
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| Rok vydání: | 2020 |
| Předmět: |
biology
010405 organic chemistry Extramural Cell growth Stereochemistry Cancer cell proliferation Organic Chemistry Ether 010402 general chemistry 01 natural sciences Article 0104 chemical sciences Ribosomal s6 kinase chemistry.chemical_compound chemistry biology.protein Phosphorylation Kaempferol Cell Proliferation Biological evaluation |
| Zdroj: | J Org Chem |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | The synthesis of two series of five kaempfer-3-ols was described. The first set all have a C-3 hydroxyl group and the second has a carboxymethoxy ether at the C-3 position. Both series have variable substitution at the C-4′ position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation. |
| Databáze: | OpenAIRE |
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