Reproductive issues in patients undergoing Hematopoietic Stem Cell Transplantation: an update

Autor: Maurizio Guida, Francesco Orio, R Rosamilio, Maria Antonietta Castaldi, Carmine Selleri, Valentina Giudice
Přispěvatelé: Guida, Maurizio, Castaldi Maria, Antonietta, Rosamilio, Rosa, Giudice, Valentina, Orio, Francesco, Selleri, Carmine
Jazyk: angličtina
Rok vydání: 2016
Předmět:
medicine.medical_specialty
medicine.medical_treatment
Reproductive medicine
Graft vs Host Disease
Hematopoietic stem cell transplantation
Review
Malignancy
03 medical and health sciences
0302 clinical medicine
Quality of life
immune system diseases
Pregnancy
hemic and lymphatic diseases
Obstetrics and Gynaecology
Medicine
Humans
Fertility preservation
Intensive care medicine
Reproductive health
030219 obstetrics & reproductive medicine
business.industry
Hematopoietic Stem Cell Transplantation
Obstetrics and Gynecology
Disease Management
Fertility Preservation
Neoplasms
Second Primary

medicine.disease
Female Urogenital Diseases
Premature ovarian failure
Surgery
surgical procedures
operative

Fertility
Oncology
030220 oncology & carcinogenesis
Osteoporosis
Female
business
Immunosuppressive Agents
Zdroj: Journal of Ovarian Research
Popis: In 1963 George Mathe announced to the world that he had cured a patient of leukaemia by means of a bone-marrow transplant. Since than much progress has been made and nowadays Hematopoietic Stem Cell Transplantation (HSCT) is considered the most effective treatment of numerous severe haematological diseases. Gynaecological complications in HSCT women represent a serious concern for these patients, but often underestimated by clinicians in the view of Overall Survival. The main gynaecological complications of HSCT are represented by: premature ovarian failure (POF), thrombocytopenia-associated menorrhagia, genital symptoms or sexual problems in course of chronic GVHD (cGVHD), osteoporosis, secondary solid tumours due to immunosuppressive drugs to treat cGVHD and severity of cGVHD, and fertility and pregnancy issues. In particular fertility-related issues are always more relevant for patients, whose life expectation is constantly growing up after HSCT. Thus, taking care of a patient undergoing HSCT should primarily include gynaecological evaluation, even before conditioning regimen or chemotherapy for the underlying malignancy, as, in our opinion, it is of great importance to ensure a complete diagnostic work-up and intervention options to guarantee maximum reproductive health and a better quality of life in HSCT women. The present review aims at describing principal features of the aforementioned gynaecological complications of HSCT, and to define, on the basis of current international literature, a specific protocol for the prevention, diagnosis, management and follow-up of gynaecological complications of both autologous and heterologous transplantation, before and after the procedure.
Databáze: OpenAIRE