Impaired antioxidant HDL function is associated with premature myocardial infarction
| Autor: | Irene M. Lang, Johann Wojta, Georg Goliasch, Christina Binder, Elisabeth Dostal, Martin Schillinger, Gerald Maurer, Stanislav Oravec, Hermann Blessberger, Kurt Huber, Lore Schrutka, Klaus Distelmaier, Franz Wiesbauer |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant Adolescent medicine.medical_treatment Clinical Biochemistry Myocardial Infarction Coronary Artery Disease Logistic regression Biochemistry Antioxidants Coronary artery disease chemistry.chemical_compound Young Adult High-density lipoprotein Risk Factors Internal medicine medicine Humans Myocardial infarction Aged Aged 80 and over Premature cad Cholesterol business.industry Cholesterol HDL General Medicine Middle Aged medicine.disease Young age chemistry Case-Control Studies Cardiology lipids (amino acids peptides and proteins) Female business |
| Zdroj: | European journal of clinical investigation. 45(7) |
| ISSN: | 1365-2362 |
| Popis: | Background There is growing evidence that the predictive value of HDL cholesterol levels for cardiovascular risk stratification is limited in patients with coronary artery disease (CAD). HDL function seems to be a more sensitive surrogate of cardiovascular risk estimation than simple serum levels. Therefore, we aimed to assess whether impaired antioxidant HDL function is involved in the development of premature acute myocardial infarction (AMI). Methods In this multicentre case–control study, we compared the antioxidant function of HDL, measured by the HDL inflammatory index (HII), and HDL particle size in 184 patients comprising 92 patients with AMI at a very young age (≤40 years of age) and 92 age- and gender-matched controls. Results Antioxidant capacities of HDL were significantly impaired in the acute phase of AMI (HII of 1·50 [IQR 1·10–1·74] vs. 0·56 [IQR 0·41–0·86] in controls, P |
| Databáze: | OpenAIRE |
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