Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens
| Autor: | Henrik H. De Fine Licht, Matthew D. Maust, Kristen L. Wickert, Chris Simon, Matthew T. Kasson, Ellie J. Spahr, Kathie T. Hodge, Greg R. Boyce, William J. Davis, Terry Gullion, Dylan P. G. Short, Teiya Kijimoto, Timothy Y. James, Gene Kritsky, Amy M. Metheny, Richard A. Humber, Jason C. Slot, Cameron M. Stauder, Nidia Arguedas, John R. Cooley, Jørgen Eilenberg, Jason E. Stajich, Angie M. Macias, Emile Gluck-Thaler, Dan Mozgai, Matthew C. Berger, Daniel G. Panaccione |
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| Rok vydání: | 2018 |
| Předmět: |
Tryptamine
0106 biological sciences Psilocin Plant Science Entomopathogen Biology Magicicada 010603 evolutionary biology 01 natural sciences Article Psilocybin Microbiology chemistry.chemical_compound Invertebrate pathology 03 medical and health sciences Metabolomics Okanagana medicine Ecology Evolution Behavior and Systematics 030304 developmental biology Psychoactive plant Platypedia 0303 health sciences Mushroom Ecology Host (biology) Ecological Modeling fungi Massospora biology.organism_classification 3. Good health Spore Entomophthorales Amphetamine Cathinone chemistry Periodical cicadas Biological dispersal Zoopagomycota Massospora cicadina 010606 plant biology & botany medicine.drug |
| Zdroj: | Boyce, Greg; Gluck-Thaler, Emile; Slot, Jason; Stajich, Jason; Davis, William; James, Tim; et al.(2018). Psychoactive plant-and mushroom-associated alkaloids from two behavior modifying cicada pathogens. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/3wz7q482 Boyce, G R, Gluck-Thaler, E, Slot, J C, Stajich, J E, Davis, W J, James, T Y, Cooley, J R, Panaccione, D G, Eilenberg, J, De Fine Licht, H H, Macias, A M, Berger, M C, Wickert, K L, Stauder, C M, Spahr, E J, Maust, M D, Metheny, A M, Simon, C, Kritsky, G, Hodge, K T, Humber, R A, Gullion, T, Short, D P G, Kijimoto, T, Mozgai, D, Arguedas, N & Kasson, M T 2019, ' Psychoactive plant-and mushroom-associated alkaloids from two behavior modifying cicada pathogens ', Fungal Ecology, vol. 41, pp. 147-164 . https://doi.org/10.1016/j.funeco.2019.06.002 Fungal ecology |
| DOI: | 10.1101/375105 |
| Popis: | Entomopathogenic fungi routinely kill their hosts before releasing infectious spores, but select species keep insects alive while sporulating, which enhances dispersal. Transcriptomics and metabolomics studies of entomopathogens with post-mortem dissemination from their parasitized hosts have unraveled infection processes and host responses, yet mechanisms underlying active spore transmission by Entomophthoralean fungi in living insects remain elusive. Here we report the discovery, through metabolomics, of the plant-associated amphetamine, cathinone, in four Massospora cicadina-infected periodical cicada populations, and the mushroom-associated tryptamine, psilocybin, in annual cicadas infected with Massospora platypediae or Massospora levispora, which appear to represent a single fungal species. The absence of some fungal enzymes necessary for cathinone and psilocybin biosynthesis along with the inability to detect intermediate metabolites or gene orthologs are consistent with possibly novel biosynthesis pathways in Massospora. The neurogenic activities of these compounds suggest the extended phenotype of Massospora that modifies cicada behavior to maximize dissemination is chemically-induced. |
| Databáze: | OpenAIRE |
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