Interleukin 25 (IL‑25) expression in cholangiocarcinoma
| Autor: | Attapol Titapun, Supakit Kaewsarabhumi, Siriporn Proungvitaya, Temduang Limpaiboon, Doungdean Tummanatsakun, Prakasit Sa‑Ngaimwibool, Patcharaporn Tippayawat, Tanakorn Proungvitaya |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Cell information science Biology medicine.disease_cause Metastasis 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine metastasis cardiovascular diseases Oncogene fungi tissue Articles interleukin-25 Cell cycle medicine.disease Molecular medicine medicine.anatomical_structure Oncology Tumor progression 030220 oncology & carcinogenesis immunohistochemistry cardiovascular system Cancer research Immunohistochemistry 030211 gastroenterology & hepatology prognosis cholangiocarcinoma Carcinogenesis |
| Zdroj: | Molecular and Clinical Oncology |
| ISSN: | 2049-9469 2049-9450 |
| Popis: | Various cytokines are involved in carcinogenesis and tumor progression. Some tumor cells produce cytokines by themselves. Using secretome analysis, a high expression of APEX-1 was found in cholangiocarcinoma (CCA) cell lines. During this secretome analysis, it was found that CCA cell lines overexpressed some cytokines and related molecules, including interleukin 25 (IL-25). In the present study, we first performed precise secretome analysis on cytokines and related molecules in CCA cell lines and identified that IL-25 was overexpressed in CCA cell lines. Then, using immunohistochemical methods, we investigated the expression of IL-25 in the cancer tissues from 20 CCA patients in Northeast Thailand. Correlation between IL-25 expression levels and patients' clinical parameters were analyzed. The results showed that IL-25 expression was significantly (P |
| Databáze: | OpenAIRE |
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