Incidence and severity of ifosfamide-induced encephalopathy
| Autor: | J. Tischer, Christina Rieger, Xaver Schiel, M. Fiegl, Helmut Ostermann |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Encephalopathy Cohort Studies Risk Factors Neoplasms Internal medicine medicine Humans Pharmacology (medical) Ifosfamide Stage (cooking) Antineoplastic Agents Alkylating Aged Retrospective Studies Pharmacology Chemotherapy Dose-Response Relationship Drug business.industry Incidence (epidemiology) Retrospective cohort study Middle Aged medicine.disease Surgery Oncology Toxicity Female Neurotoxicity Syndromes business medicine.drug Cohort study |
| Zdroj: | Anti-Cancer Drugs. 15:347-350 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/00001813-200404000-00006 |
| Popis: | This retrospective trial was performed to determine risk factors, incidence and severity of ifosfamide-induced encephalopathy in correlation with patient and treatment characteristics. Patients receiving ifosfamide were included consecutively with no restrictions concerning disease, prior chemotherapy or disease stage. Incidence and severity of encephalopathy were graduated according to common toxicity criteria. Between July 2001 and July 2002, 60 patients (32 male, 28 female, median age 47.5 years) were included; 26.6% of the patients (n = 16) developed neurological symptoms [grade 1: 6.7% (n = 4); grade 2: 3.3% (n = 2); grade 3: 11.7% (n = 7); grade 4: 5% (n = 3)]. Encephalopathy occurred for the first time in 87.5% (n = 14) in chemotherapy courses 1 and 2. In 56.25% (n = 9) of these 16 patients only one episode was observed. There was no significant difference concerning age (38 versus 50 years, p = 0.08) and dosage (median 2.9 versus 2.8 g, p = 0.74) between patients with and without encephalopathy. No risk factors could be identified by this study, suggesting an individual predisposition in each patient. On the other hand, ifosfamide can be administered in older patients without increased risk of neurotoxicity. |
| Databáze: | OpenAIRE |
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