Occurrence, characteristics, and patterns of HIV-1 and HIV-2 western blot indeterminate sera in low risk populations in West Virginia and pre-AIDS Africa
| Autor: | Andrew H. Schindzielorz, Maurice A. Mufson, Robert B. Belshe |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Zimbabwe Adolescent Population Blotting Western HIV Antibodies Serology Immunoenzyme Techniques Sex Factors Acquired immunodeficiency syndrome (AIDS) Antigen Risk Factors Virology HIV Seropositivity medicine Humans False Positive Reactions education Child education.field_of_study medicine.diagnostic_test biology business.industry Age Factors virus diseases Infant West Virginia medicine.disease Liberia Kenya Infectious Diseases Immunoassay Child Preschool Immunology HIV-2 biology.protein HIV-1 Parasitology Female Viral disease Antibody business Horizontal transmission |
| Zdroj: | The American journal of tropical medicine and hygiene. 42(5) |
| ISSN: | 0002-9637 |
| Popis: | To further characterize HIV-1 and HIV-2 Western blot indeterminate (IWB) sera, 402 sera from 318 healthy low-risk individuals from West Virginia and 159 African sera obtained in the pre-AIDS era (1968–1972) were studied. All IWB sera tested for antigen by HIV-1 enzyme immunoassay (EIA-Ag) were negative. HIV-1 and HIV-2 IWB reactivity occurred independent of HIV-1 and HIV-2 false-positive testing for antibody by enzyme immunoassay (EIA-Ab) and no cross-reactions between HIV-1 and HIV-2 IWB patterns were detected. The IWB patterns were reproducible, demonstrated no age or sex related pattern, and showed no evidence of vertical or horizontal transmission. The African sera exhibited a significantly higher number of IWB patterns. IWB reactivity in HIV-1 and HIV-2 seronegative individuals may not be viral in origin and the occurrence of IWB pattern may vary among populations. |
| Databáze: | OpenAIRE |
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