Invasive aspergillosis in human immunodeficiency virus-infected children
| Autor: | Neelam Giri, Thomas J. Walsh, Corina E. Gonzalez, Philip A. Pizzo, Daiva Shetty |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Antifungal Agents Neutropenia Adolescent Opportunistic infection medicine.medical_treatment HIV Infections Aspergillosis Diagnosis Differential Humans Medicine Child Mycosis Retrospective Studies Lung AIDS-Related Opportunistic Infections business.industry Respiratory disease Infant Immunosuppression medicine.disease CD4 Lymphocyte Count Surgery Infectious Diseases medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Female Differential diagnosis business |
| Zdroj: | The Pediatric Infectious Disease Journal. 16:216-221 |
| ISSN: | 0891-3668 |
| Popis: | Background. Aspergillosis is an uncommon yet serious opportunistic infection in patients with AIDS. It has been extensively reported in HIV-infected adult patients. To our knowledge there are no studies that describe the epidemiology, clinical manifestations and outcome of aspergillosis in a large HIV-infected pediatric population. Methods. We reviewed the records of all 473 HIV-infected children followed in the Pediatric Branch of the National Cancer Institute for 9 years from 1987 through 1995 for the presence of Aspergillus infection. Results. Seven (1.5%) patients developed invasive aspergillosis during the study period. All patients had low CD4 counts reflecting severe immunosuppression. Sustained neutropenia (>7 days) or corticosteroid therapy as a predisposing factor for invasive aspergillosis was encountered in only two patients (28%). Invasive pulmonary aspergillosis developed in five patients and cutaneous aspergillosis in two. The most common presenting features in patients with pulmonary aspergillosis were fever, cough and dyspnea. Patients with cutaneous aspergillosis were diagnosed during life and successfully treated with amphotericin B and surgery, whereas diagnosis of pulmonary aspergillosis was made clinically in only one patient. Conclusions. Aspergillosis is an uncommon but highly lethal opportunistic infection in HIV-infected children. Invasive pulmonary aspergillosis should be considered in the differential diagnosis in febrile, HIV-infected children with persistent pulmonary infiltrates. |
| Databáze: | OpenAIRE |
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