Women’s experiences receiving abnormal prenatal chromosomal microarray testing results
| Autor: | Barbara A. Bernhardt, Danielle Soucier, Melissa Savage, Karen Hanson, Ronald J. Wapner, Laird G. Jackson |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Conventional cytogenetics Microarray Genetic counseling Chromosome Disorders Genetic Counseling Pilot Projects Prenatal diagnosis Truth Disclosure Article Pregnancy Prenatal Diagnosis medicine Humans Genetic Testing Prospective cohort study Genetics (clinical) Genetic testing Chromosome Aberrations Gynecology medicine.diagnostic_test Obstetrics business.industry Obstetrics and Gynecology General Medicine medicine.disease Family medicine Female Abnormal results DNA microarray business Research setting Qualitative research |
| Zdroj: | Genetics in Medicine. 15:139-145 |
| ISSN: | 1098-3600 |
| Popis: | Genomic microarrays can detect copy-number variants not detectable by conventional cytogenetics. This technology is diffusing rapidly into prenatal settings even though the clinical implications of many copy-number variants are currently unknown. We conducted a qualitative pilot study to explore the experiences of women receiving abnormal results from prenatal microarray testing performed in a research setting. Participants were a subset of women participating in a multicenter prospective study “Prenatal Cytogenetic Diagnosis by Array-based Copy Number Analysis.” Telephone interviews were conducted with 23 women receiving abnormal prenatal microarray results. We found that five key elements dominated the experiences of women who had received abnormal prenatal microarray results: an offer too good to pass up, blindsided by the results, uncertainty and unquantifiable risks, need for support, and toxic knowledge. As prenatal microarray testing is increasingly used, uncertain findings will be common, resulting in greater need for careful pre- and posttest counseling, and more education of and resources for providers so they can adequately support the women who are undergoing testing. Genet Med 2013:15(2):139–145 |
| Databáze: | OpenAIRE |
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