Unexpected opioid activity in a known class of drug
| Autor: | Trevor J. Petcher, W. Benson, E. Finner, Richard Maurer, Dietmar Römer, H. Zeugner, Heinz H. Büscher, Ronald C. Hill, P. W. Thies, W. Milkowski |
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| Rok vydání: | 1982 |
| Předmět: |
Agonist
Benzodiazepine Binding Sites medicine.drug_class Chemistry Receptors Opioid kappa Guinea Pigs Analgesic General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Benzodiazepines Mice Opioid In vivo Receptors Opioid medicine Animals Rabbits General Pharmacology Toxicology and Pharmaceutics Tifluadom Binding site Opiate medicine.drug |
| Zdroj: | Life Sciences. 31:1217-1220 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(82)90346-0 |
| Popis: | Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no dependence potential. |
| Databáze: | OpenAIRE |
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