T-helper and regulatory T-cell cytokines in the peripheral blood of patients with active alopecia areata
| Autor: | Vinod Sharma, M.K. Tembhre |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Alopecia Areata Regulatory T cell Enzyme-Linked Immunosorbent Assay Dermatology T-Lymphocytes Regulatory Immune tolerance Pathogenesis Atopy Young Adult Immunity Interferon Internal medicine medicine Humans business.industry Interleukin T-Lymphocytes Helper-Inducer Alopecia areata medicine.disease medicine.anatomical_structure Endocrinology Case-Control Studies Immunology Cytokines Female business medicine.drug |
| Zdroj: | British Journal of Dermatology. 169:543-548 |
| ISSN: | 0007-0963 |
| DOI: | 10.1111/bjd.12396 |
| Popis: | SummaryBackground Alteration in T-lymphocyte function and cytokines secreted by T-cell subsets has been proposed in the immunopathogenesis of alopecia areata (AA). The role of T-helper and regulatory T-cell cytokines in the pathogenesis of active AA has not been established. Objectives To assess the role of hallmark cytokines of T-helper cells (Th1, Th2 and Th17) and regulatory T cells (Tregs) in the pathogenesis of AA, and its clinical correlation. Methods Fifty-one patients with AA and 45 age- and sex-matched healthy control subjects were included in the study. Serum interleukin (IL)-2, interferon (IFN)-γ, IL-10, IL-13, IL-17A and transforming growth factor (TGF)-β1 were measured by enzyme-linked immunosorbent assay in both groups. Correlation of serum cytokine levels with age, sex, disease subtype and duration, number of patches on the scalp, associated autoimmune disorders and atopy was studied. Results The serum cytokine levels of IL-2, IFN-γ, IL-13 and IL-17A were significantly increased, and serum TGF-β1 levels were significantly decreased (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text