Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans
| Autor: | Anne Ferlay, Maria Rosaria Melis, Maria Cristina Mele, Lina Cordeddu, Elisabetta Murru, Margherita Addis, Yves Chilliard, M. Coakley, Catherine Stanton, Erika Desogus, G. Piredda, Gianfranca Carta, Giorgio Cannelli, Sebastiano Banni, R.P. Ross, Claudia Manca, Hastimansooreh Ansar |
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| Přispěvatelé: | Dipartimento Scienze Biomediche, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Teagasc Agriculture and Food Development Authority (Teagasc), APC Microbiome Ireland, University College Cork (UCC), Servizio per la Ricerca nei Prodotti di Origine Animale, AGRIS sardegna, Fondazione Policlinico Universitario Agostino Gemelli, EU Project QLK1-2002-02362, INNOVA.RE-WP 2.3-P.O.R.-F.E.S.R., Science Foundation Ireland (SFI), SFI/12/RC/2273, Unité Mixte de Recherches sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Conjugated Conjugated linoleic acid [SDV]Life Sciences [q-bio] Peroxisome proliferator-activated receptor fromage ruminant Highly unsaturated fatty acids (HUFA) lcsh:Chemistry Plasma chemistry.chemical_compound Linseed oil Cheese Ruminant fatty acids (FA) Linoleic Acids Conjugated Food science lcsh:QH301-705.5 Spectroscopy Omega-3 2. Zero hunger chemistry.chemical_classification biology Chemistry Fatty Acids clinical trial General Medicine Peroxisome Cheese intake 3. Good health Computer Science Applications conjugated linoleic acids (CLA) Clinical trial Linoleic Acids Female Adult cheese highly unsaturated fatty acids (HUFA) plasma food.ingredient Alpha (ethology) n-3 fatty acid Catalysis Article Inorganic Chemistry 03 medical and health sciences food acide gras n 3 Settore MED/41 - ANESTESIOLOGIA Fatty Acids Omega-3 Humans PPAR alpha Physical and Theoretical Chemistry Molecular Biology micromass Conjugated linoleic acids (CLA) 030109 nutrition & dietetics Organic Chemistry Lipid metabolism Fatty acids (FA) biology.organism_classification acide linoléique Diet lcsh:Biology (General) lcsh:QD1-999 |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2018, 19 (6), pp.1730. ⟨10.3390/ijms19061730⟩ Volume 19 Issue 6 International Journal of Molecular Sciences 6 (19), 1730. (2018) International Journal of Molecular Sciences, Vol 19, Iss 6, p 1730 (2018) |
| ISSN: | 1661-6596 1422-0067 |
| DOI: | 10.3390/ijms19061730⟩ |
| Popis: | n-3 highly unsaturated fatty acids (n-3 HUFA) directly and indirectly regulate lipid metabolism, energy balance and the inflammatory response. We investigated changes to the n-3 HUFA score of healthy adults, induced by different types and amounts of conjugated linoleic acid (CLA)-enriched (ENCH) cheeses consumed for different periods of time, compared to dietary fish oil (FO) pills (500 mg, each containing 100 mg of eicosapentaenoic and docosahexaenoic acids&mdash EPA+DHA) or &alpha linolenic acid (ALA)-rich linseed oil (4 g, containing 2 g of ALA). A significant increase in the n-3 HUFA score was observed, in a dose-dependent manner, after administration of the FO supplement. In terms of the impact on the n-3 HUFA score, the intake of ENCH cheese (90 g/day) for two or four weeks was equivalent to the administration of one or two FO pills, respectively. Conversely, the linseed oil intake did not significantly impact the n-3 HUFA score. Feeding ENCH cheeses from different sources (bovine, ovine and caprine) for two months improved the n-3 HUFA score by increasing plasma DHA, and the effect was proportional to the CLA content in the cheese. We suggest that the improved n-3 HUFA score resulting from ENCH cheese intake may be attributed to increased peroxisome proliferator-activated receptor alpha (PPAR-&alpha ) activity. This study demonstrates that natural ENCH cheese is an alternative nutritional source of n-3 HUFA in humans. |
| Databáze: | OpenAIRE |
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