Screening and quantification of fourteen synthetic antidiabetic adulterants in herbal pharmaceuticals and health foods by HPLC and confirmation by LC-Q-TOF-MS/MS
| Autor: | Xin Hu, Shuo Xu, Pengfei Jin, Wenfeng Xu, Xiaorong He, Yongmei Kuang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug Compounding
Health Toxicology and Mutagenesis Food Contamination Nateglinide Toxicology High-performance liquid chromatography Tandem Mass Spectrometry medicine Humans Hypoglycemic Agents Gliclazide Buformin Adulterant Chromatography Chemistry Public Health Environmental and Occupational Health General Chemistry General Medicine Repaglinide Glimepiride Pharmaceutical Preparations Diet Healthy Drug Contamination Food Analysis Gliquidone Chromatography Liquid Food Science medicine.drug |
| DOI: | 10.6084/m9.figshare.9983351 |
| Popis: | A procedure was established and fully validated for the screening and quantification of fourteen synthetic antidiabetic adulterants in herbal pharmaceuticals and health foods, including metformin (MF), buformin (BF), phenformin (PHF), rosiglitazone (RGZ), pioglitazone (PGZ), chlorpropamide (CPM), glipizide (GPZ), tolbutamide (TBM), gliclazide (GCZ), glibenclamide (GBM), glimepiride (GMR), repaglinide (RGN), gliquidone (GQD) and nateglinide (NGN). The samples were extracted by methanol and separated by HPLC. Retention times and ultraviolet spectra were used for the preliminary screening, and the suspected adulterants were then confirmed by liquid chromatography-quadrupole-time of flight mass spectrometry (LC-Q-TOF-MS/MS) and quantified by HPLC. The developed procedure was successfully applied to assess twenty-four herbal samples, and PHF, GCZ, GBM, MF, GPZ and BF were found in many. To the best of our knowledge, this is the first report of simultaneous screening and quantification of these fourteen synthetic antidiabetic adulterants from any matrix. |
| Databáze: | OpenAIRE |
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