Effect of different doses of pregabalin on skeletal muscle ischaemia-reperfusion injury in rats
| Autor: | Y. Kilic, A. Kilicarslan, Hüseyin Demirtaş, Muhammed Enes Aydin, Abdullah Özer, Mehmet Arslan, Erkan Iriz, Mustafa Kavutcu, Ayşegül Küçük, H. T. Dogan, Levent Ozturk, Aslihan Cavunt Bayraktar |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Economics and Econometrics medicine.medical_specialty Ischaemia-reperfusion injury Analgesic Pregabalin Histopathology Apoptosis Serum Albumin Human Hind limb ischemia reperfusion IMA Gastrocnemius muscle Internal medicine Materials Chemistry Media Technology medicine Animals Rats Wistar Muscle Skeletal Serum Albumin PON biology business.industry Ischemia-modified albumin Paraoxonase Skeletal muscle Forestry Rats Disease Models Animal Oxidative Stress medicine.anatomical_structure Endocrinology Anesthesia Reperfusion Injury biology.protein business Biomarkers medicine.drug |
| Popis: | AIM/INTRODUCTION Analgesic, anti-inflammatory and anti-apoptotic effects of pregabalin have been shown previously. In this study, we investigated the protective effect of different doses of pregabalin on skeletal muscle IR injury in rats. MATERIALS AND METHODS 24 rats were randomly divided into 4 groups (Control, Ischaemia-Reperfusion (IR), IR-Pregabalin 50 mg, IR-Pregabalin 200 mg). Following IR, serum Ischemia Modified Albumin (IMA) and tissue Paraoxonase (PON) were studied and gastrocnemius muscle tissue was removed for histopathologic examination. RESULTS Interstitial inflammation was higher in the IR group than in the control and Pregabalin 200 mg groups (p = 0.037, p = 0.037, respectively). Congestion was higher in the IR group than in the control, Pregabalin 50 and 200 mg groups (p = 0.001, p = 0.004, p = 0.004, respectively). PON was lower in the IR group than in the Control, Pregabalin 50 and 200 mg groups (p = 0.001, p = 0.007, p = 0.015, respectively). IMA was higher in the IR group than in the Control, Pregabalin 50 and 200 mg groups (p < 0.0001, all). CONCLUSION We think that administration of pregabalin, more prominent at 200 mg, can reverse the injury that occurs in the skeletal muscle of IR-induced rats. Pregabalin can be safely used for analgesia in cases of IR (Tab. 2, Fig. 9, Ref. 41). |
| Databáze: | OpenAIRE |
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