Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation
| Autor: | Cormac T. Taylor, John F. Garvey, Walter T. McNicholas |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Inflammation Disease Bioinformatics Internal medicine medicine Animals Humans Hypoxia Transcription factor Obstructive sleep apnoea syndrome Sleep Apnea Obstructive business.industry Respiratory disease Sleep apnea Intermittent hypoxia Hypoxia (medical) medicine.disease respiratory tract diseases Endocrinology Cardiovascular Diseases Cytokines medicine.symptom business Transcription Factors |
| Zdroj: | European Respiratory Journal. 33:1195-1205 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00111208 |
| Popis: | There is increasing evidence that intermittent hypoxia plays a role in the development of cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of inflammatory pathways. The development of translational models of intermittent hypoxia has allowed investigation of its role in the activation of inflammatory mechanisms and promotion of cardiovascular disease in OSAS. There are noticeable differences in the response to intermittent hypoxia between body tissues but the hypoxia-sensitive transcription factors hypoxia-inducible factor-1 and nuclear factor-kappaB appear to play a key role in mediating the inflammatory and cardiovascular consequences of OSAS. Expanding our understanding of these pathways, the cross-talk between them and the activation of inflammatory mechanisms by intermittent hypoxia in OSAS will provide new avenues of therapeutic opportunity for the disease. |
| Databáze: | OpenAIRE |
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