Nanotoxoid vaccination protects against opportunistic bacterial infections arising from immunodeficiency
| Autor: | Jiarong Zhou, Nishta Krishnan, Zhongyuan Guo, Christian J. Ventura, Maya Holay, Qiangzhe Zhang, Xiaoli Wei, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang |
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| Rok vydání: | 2022 |
| Předmět: |
and promotion of well-being
Multidisciplinary Virulence Factors Prevention Vaccination Bacterial Infections Pneumonia Prevention of disease and conditions Vaccine Related Rare Diseases Infectious Diseases Good Health and Well Being 3.4 Vaccines Pseudomonas aeruginosa Pneumonia & Influenza Animals Immunization Infection Lung |
| Zdroj: | Science advances, vol 8, iss 36 |
| Popis: | The rise in nosocomial infections caused by multidrug-resistant pathogens is a major public health concern. Patients taking immunosuppressants or chemotherapeutics are naturally more susceptible to infections. Thus, strategies for protecting immunodeficient individuals from infections are of great importance. Here, we investigate the effectiveness of a biomimetic nanotoxoid vaccine in defending animals with immunodeficiency against Pseudomonas aeruginosa . The nanotoxoids use a macrophage membrane coating to sequester and safely present bacterial virulence factors that would otherwise be too toxic to administer. Vaccination with the nanoformulation results in rapid and long-lasting immunity, protecting against lethal infections despite severe immunodeficiency. The nanovaccine can be administered through multiple routes and is effective in both pneumonia and septicemia models of infection. Mechanistically, protection is mediated by neutrophils and pathogen-specific antibodies. Overall, nanotoxoid vaccination is an attractive strategy to protect vulnerable patients and could help to mitigate the threat posed by antibiotic-resistant superbugs. |
| Databáze: | OpenAIRE |
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