Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity
| Autor: | Paul Imbach, B. Imholz, H. P. Wagner, Robert McMillan, Diane J. Nugent, Gerhard Gaedicke, Victor S. Blanchette, A. Burek-Kozlowska, Adrian C. Newland, James B. Bussel, Martin H. Schöni, E. Gugler, J. Akatsuka, A. Gianella-Borradori, Andreas Hirt, Andreas Morell |
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| Rok vydání: | 1995 |
| Předmět: |
Autoimmunity
chemical and pharmacologic phenomena medicine.disease_cause Pathogenesis Immune system immune system diseases hemic and lymphatic diseases Humans Medicine Platelet Immunity Cellular Purpura Thrombocytopenic Idiopathic biology business.industry Therapeutic effect Autoantibody Immunoglobulins Intravenous biochemical phenomena metabolism and nutrition medicine.disease Thrombocytopenic purpura Antibody Formation Pediatrics Perinatology and Child Health Immunology biology.protein bacteria Antibody business |
| Zdroj: | European Journal of Pediatrics. 154:S60-S64 |
| ISSN: | 1432-1076 0340-6199 |
| Popis: | In honour of Professor Rossi's 80th birthday we review the development of our understanding of the immune and auto-immune nature of the pathogenesis of immune thrombocytopenic purpura (ITP). The immune aspects have been documented by postviral alterations of the cellular and humoral immune system, by new methods of specific auto-antibody detection against platelet glycoproteins and by the therapeutic effect of administering immunoglobulin concentrate from healthy blood donors. The various possible mechanisms of action of immunoglobulin treatment have led to use of this treatment as an alternative for other immune-related disorders. The treatment of severe chronic ITP in children, however, remains unsatisfactory. With a new international clinical and laboratory study of children and adolescents with early chronic ITP we are continuing the investigation of the pathogenesis and treatment of ITP. |
| Databáze: | OpenAIRE |
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