Cytokine Clearances in Critically Ill Patients on Continuous Renal Replacement Therapy
| Autor: | Sevag Demirjian, Jay L. Koyner, Suneel M. Udani, Ling Xin Chen, Sharon Trevino, Patrick T. Murray |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Critical Illness 030232 urology & nephrology Urology Urine law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Renal Dialysis Medicine Humans Renal replacement therapy Prospective Studies Interleukin 6 Aged Aged 80 and over biology business.industry Critically ill Acute kidney injury 030208 emergency & critical care medicine Hematology General Medicine Acute Kidney Injury Middle Aged medicine.disease Continuous venovenous hemofiltration Cytokine Nephrology biology.protein Cytokines Female Hemofiltration business |
| Zdroj: | Blood purification. 46(4) |
| ISSN: | 1421-9735 |
| Popis: | Background/Aims: We sought to quantify any differences in cytokine clearance between continuous venovenous hemofiltration (CVVH-convective) compared to continuous venovenous hemodialysis (CVVHD-diffusive). Methods: We conducted a 20 patient, multicenter, prospective, open-label randomized trial (CVVH or CVVHD) at continuous renal replacement therapy (CRRT) initiation. Blood, urine, and effluent were collected at 0, 4, 24, and 48 h after initiation of CRRT. Serum electrolytes, cytokines levels, and clearances were measured. Cytokines studies included IL-1β, IL-1RA, IL-6, IL-10, and TNFα. Results: We randomized 20 patients to receive CRRT. After 4 h of CRRT there was no difference in total cytokine levels or change in cytokine concentrations across the 2 groups. With the exception of IL-1 RA, all cytokines levels decreased across patient groups regardless of modality. There was no significant difference in cytokine concentration across CRRT modality for any time point. Conclusion: Within the first 4 h of CRRT initiation, there is no significant difference between cytokine or solute clearance between CVVH and CVVHD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |