Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: Their correlation with activated Akt, LRP/MVP and P-glycoprotein expression
| Autor: | Norio Wake, Yuji Basaki, Michihiko Kuwano, Kazuto Nishio, Mayumi Ono, Masazumi Tsuneyoshi, Yoshihiro Ohishi, Hiroaki Kobayashi, Toshio Hirakawa, Yoshinao Oda |
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| Rok vydání: | 2007 |
| Předmět: |
Receptors
CXCR4 Cancer Research Microarray Adenocarcinoma Biology CXCR4 Ovarian carcinoma Antineoplastic Combined Chemotherapy Protocols Gene expression medicine Humans ATP Binding Cassette Transporter Subfamily B Member 1 Protein kinase B Aged Neoplasm Staging Vault Ribonucleoprotein Particles Ovarian Neoplasms General Medicine Middle Aged Y box binding protein 1 Prognosis medicine.disease Immunohistochemistry Survival Analysis Oncology Cancer research Female Y-Box-Binding Protein 1 Ovarian cancer Proto-Oncogene Proteins c-akt Nuclear localization sequence |
| Zdroj: | Cancer Science. 98:1020-1026 |
| ISSN: | 1349-7006 1347-9032 |
| Popis: | The nuclear localization of Y-box-binding protein-1 (YB-1) is known to be a poor prognostic factor in several human malignancies, including ovarian carcinoma. Following on from our basic study dealing with microarray analyses of YB-1-associated gene expression in ovarian cancer cells, we examined whether nuclear localization of YB-1 is associated with the expression of CXCR4, a vault protein named lung resistance-related vault protein (LRP/MVP), phosphorylated Akt (p-Akt) or P-glycoprotein (P-gp) in human ovarian carcinoma. Fifty-three surgically resected ovarian carcinomas treated with paclitaxel and carboplatin were examined immunohistochemically for nuclear YB-1 expression and intrinsic expression of p-Akt, P-gp, LRP/MVP and CXCR4. Nuclear expression of YB-1 demonstrated significant correlation with p-Akt, P-gp and LRP expression, but no relationship with CXCR4 expression. By multivariate analysis, only YB-1 nuclear expression and CXCR4 expression were independent prognostic factors with regard to overall survival. These results indicate that YB-1 nuclear expression and CXCR4 expression are important prognostic factors in ovarian carcinoma. |
| Databáze: | OpenAIRE |
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