Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases
| Autor: | Evans R. Fernandez-Perez, Swati Phalke, Briana Barkes, Kira Rubtsova, Linda S. Powers, James L. Crooks, Lisa A. Maier, Anatoly V. Rubtsov, Katja Aviszus, Philippa Marrack, John W. Kappler, Nabeel Hamzeh, Brenda Warner |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Cell B-Lymphocyte Subsets CD11c Receptors Cell Surface Receptors Fc Critical Care and Intensive Care Medicine Berylliosis Young Adult Sarcoidosis Pulmonary medicine Humans In patient Receptors Immunologic Aged Aged 80 and over Lung business.industry Membrane Proteins Middle Aged medicine.disease Peripheral blood CD11c Antigen medicine.anatomical_structure Case-Control Studies Immunology Female Receptors Complement 3d Sarcoidosis business T-Box Domain Proteins Bronchoalveolar Lavage Fluid Hypersensitivity pneumonitis Beryllium Disease Alveolitis Extrinsic Allergic |
| Zdroj: | American journal of respiratory and critical care medicine. 202(7) |
| ISSN: | 1535-4970 |
| Popis: | Rationale: A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice and humans with infections or autoimmune diseases. Because depletion of these cells might be valuable in patients with certain lung diseases, the goal was to find out if ABC-like cells were at elevated levels in such patients.Objectives: To measure ABC-like cell percentages in patients with lung granulomatous diseases.Methods: Peripheral blood and BAL cells from patients with sarcoidosis, beryllium sensitivity, or hypersensitivity pneumonitis and healthy subjects were analyzed for the percentage of B cells that were ABC-like, defined by expression of CD11c, low levels of CD21, FcRL 1-5 (Fc receptor-like protein 1-5) expression, and, in some cases, T-bet.Measurements and Main Results: ABC-like cells in blood were at low percentages in healthy subjects and higher percentages in patients with sarcoidosis as well as at high percentages among BAL cells of patients with sarcoidosis, beryllium disease, and hypersensitivity pneumonitis. Treatment of patients with sarcoidosis led to reduced percentages of ABC-like cells in blood.Conclusions: Increased levels of ABC-like cells in patients with sarcoidosis may be useful in diagnosis. The increase in percentage of ABC-like cells in patients with lung granulomatous diseases and decrease in treated patients suggests that depletion of these cells may be valuable. |
| Databáze: | OpenAIRE |
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