Distribution of muscarinic receptors and acetylcholinesterase in the rat heart
| Autor: | John C. Hancock, Margaret W. Hougland, Donald B. Hoover |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Chronotropic medicine.medical_specialty Physiology Bronchi Stimulation Biology Nerve Fibers Parasympathetic Nervous System Internal medicine Muscarinic acetylcholine receptor medicine Muscarinic acetylcholine receptor M4 Animals Myocardium General Neuroscience Muscarinic acetylcholine receptor M3 Rats Inbred Strains Muscarinic acetylcholine receptor M2 Anatomy Receptors Muscarinic Rats Quinuclidinyl Benzilate Endocrinology Butyrylcholinesterase Dromotropic Acetylcholinesterase cardiovascular system Autoradiography Cholinergic Neurology (clinical) |
| Zdroj: | Journal of the Autonomic Nervous System. 19:59-66 |
| ISSN: | 0165-1838 |
| Popis: | Experiments were performed to determine the degree of overlap in the distribution of muscarinic receptors and cholinergic innervation of the rat heart. Localization of muscarinic receptors was determined by autoradiography with [3H]quinuclidinyl benzilate. Adjacent sections were stained for acetylcholinesterase to determine innervation. The distribution of muscarinic receptors and cholinergic innervation overlapped in cardiac parasympathetic ganglia, nodal tissue, His bundle-Purkinje system, vena cava and pulmonary veins. Cholinergic innervation to the right atrium was greater than to the left atrium while muscarinic receptor density was equal in the two atria. Innervation of the ventricles was confined primarily to the base of the right ventricle. A low density of muscarinic receptors was observed throughout the ventricles. Neither cholinergic innervation nor muscarinic receptors were detected in the pulmonary trunk, ascending aorta or cardiac valves. Muscarinic receptors and cholinergic innervation in the nodal regions, ventricular conduction system and myocardium probably mediate negative chronotropic, dromotropic and inotropic effects of vagal nerve stimulation. Muscarinic receptors at sites not containing cholinergic innervation may be associated with noradrenergic nerves of the myocardium. |
| Databáze: | OpenAIRE |
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