Different Application Volumes of Ethyl-Cyanoacrylate Tissue Adhesive Can Change Its Antibacterial Effects against Ocular PathogensIn Vitro

Autor:	Ivana Lopes, Romero, Tulio Pereira, Paiato, Cely Barreto, Silva, Joao Baptista, Nigro, Santiago, Malta, Lycia Mara, Jenne Mimica, H Kaz, Soong, Richard Yudi, Hida
Rok vydání:	2008
Předmět:	Staphylococcus aureus Bacteria Microbial Sensitivity Tests Biology Sensory Systems In vitro Anti-Bacterial Agents Microbiology law.invention Ethyl cyanoacrylate Klebsiella pneumoniae Cellular and Molecular Neuroscience Ophthalmology chemistry.chemical_compound Streptococcus pneumoniae chemistry Cyanoacrylate law Pseudomonas aeruginosa Escherichia coli Tissue Adhesives Cyanoacrylates Adhesive
Zdroj:	Current Eye Research. 33:813-818
ISSN:	1460-2202 0271-3683
DOI:	10.1080/02713680802437692
Popis:	To analyze the antibacterial effects in vitro of ethyl-cyanoacrylate (EC) tissue adhesive in different application volumes.Volumes of 4, 6, 8, 10, 12, 14, 25, and 35 mu l of EC were applied onto the surface of monolayer cultures of Staphylococcus aureus (ATCC25924), Streptococcus pneumoniae (ATCC49619), Escherichia coli (ATCC25922), Pseudomonas aeruginosa (ATCC27853), and Klebsiella pneumoniae (ATCC13883). The diameter of each EC drop was measured, and the area of the circle of EC (formed after its application onto the monolayer culture) was calculated. The area of the antibacterial inhibitory halo surrounding the drop of EC on the monolayer culture was calculated. The ratio between the area of the EC and of the corresponding inhibitory halo was obtained for each EC volume and for each of the 5 types of bacteria studied.EC volume-dependent inhibitory halos were seen in Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli, but not in Pseudomonas aeruginosa or Klebsiella pneumoniae.The in vitro antibacterial effect of EC against Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli varies in a dose-dependent fashion with its volume. No effect was observed against Pseudomonas aeruginosa and Klebsiella pneumoniae.
Databáze:	OpenAIRE
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