Angiotensin II reduces serotonin release in the rat subfornical organ area
| Autor: | Katsuhide Kariya, Junichi Tanaka, Masahiko Nomura |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Serotonin Microinjections Physiology Microdialysis Drinking Peptide hormone Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Internal medicine Renin–angiotensin system medicine Animals Rats Wistar Neurotransmitter Microinjection Chemistry 5-Hydroxyindoleacetic acid Angiotensin II Water Hydroxyindoleacetic Acid Subfornical organ Rats Enzyme Activation medicine.anatomical_structure hormones hormone substitutes and hormone antagonists medicine.drug Subfornical Organ |
| Zdroj: | Peptides. 24(6) |
| ISSN: | 0196-9781 |
| Popis: | In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the region of the SFO were significantly decreased by microinjection of ANG II (10 pmol, 50 nl), but not by vehicle, into the dialysis site. No significant changes in the 5-HT and 5-HIAA levels caused by ANG II were observed in the sites away from the SFO. Water ingestion significantly enhanced the amount of the decrease in the 5-HT and 5-HIAA concentrations in the SFO area elicited by the ANG II injection. These results show that ANG II may reduce the release of 5-HT in the SFO area, and imply that the 5-HT receptor mechanism in the SFO area may participate in the elicitation of the drinking behavior to ANG II. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect