Stem cell properties of Gli1-positive cells in the periodontal ligament
| Autor: | Hiroaki Takebe, Toshihide Mizoguchi, Saki Fujii, Yuri Seki, Masahiro Iijima, Nazmus Shalehin, Kazuharu Irie, Tsuyoshi Shimo, Akihiro Hosoya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Dental Cementum integumentary system Periodontal Ligament Cementoblast Regeneration (biology) Stem Cells Mesenchymal stem cell Medicine (miscellaneous) 030206 dentistry Biology Stem cell marker Zinc Finger Protein GLI1 General Biochemistry Genetics and Molecular Biology Hedgehog signaling pathway Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine stomatognathic system Periodontal fiber Hedgehog Proteins Stem cell General Dentistry Dental alveolus |
| Zdroj: | Journal of oral biosciences. 62(4) |
| ISSN: | 1880-3865 |
| Popis: | Background The periodontal ligament (PDL), which surrounds the tooth root, contains mesenchymal stem cells (MSCs) capable of differentiating into osteoblasts, cementoblasts, and fibroblasts under normal conditions. These MSCs are thought to have important roles in the repair and regeneration of injured periodontal tissues. However, since there is no useful marker for MSCs in the PDL, the characteristics and distributions of these cells remain unclear. Gli1, an essential hedgehog signaling transcription factor, functions in undifferentiated cells during embryogenesis. Previous studies have demonstrated that the dental epithelial and mesenchymal cells positive for Gli1 in developing teeth have stem cell properties, including the ability to form colonies and pluripotency. Therefore, the focus of this review is the stem cell properties of Gli1-positive cells in the PDL, with an emphasis on the differentiation ability of osteoblasts for the regeneration of periodontal tissues. Highlight Lineage tracing analysis identified Gli1-positive PDL cells as MSCs that contribute to the formation of periodontal tissues and can regenerate alveolar bone. Conclusion Gli1 is a potential stem cell marker in the PDL. A more definitive understanding of the functions of Gli1-positive cells could be useful for the development of regenerative methods using the MSCs in the PDL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect