Neurotoxic and neurobehavioral effects of kynurenines in adult insects
Autor: | Jurgen Huybrechts, Liliane Schoofs, Anja Cerstiaens, Stephen Kotanen, Karen Meylaers, Ilya Lebeau, Arnold De Loof |
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Rok vydání: | 2003 |
Předmět: |
Nervous system
Insecta Cell Survival Biophysics Endogeny Apoptosis Grasshoppers Pharmacology Biology Biochemistry Median lethal dose Nervous System Lethal Dose 50 chemistry.chemical_compound Hemolymph Anthranilic acid medicine Animals ortho-Aminobenzoates Molecular Biology Cells Cultured Kynurenine Neurons Behavior Animal Dose-Response Relationship Drug Diptera fungi Tryptophan Cell Biology Quinolinic Acid medicine.anatomical_structure chemistry Neurotoxicity Syndromes Quinolinic acid |
Zdroj: | Biochemical and biophysical research communications. 312(4) |
ISSN: | 0006-291X |
Popis: | Kynurenines are endogenous metabolites of tryptophan, which are studied extensively in vertebrates with respect to their etiological role in the pathology of various neurodegenerative disorders. In insects, metabolites of the kynurenic pathway are present in peak concentrations in the hemolymph of holometabolic species during pupation and just before eclosion. Unlike in larvae, these compounds cause severe motor dysfunction in adult species. Adult flesh flies were injected with various concentrations of these endogenous toxins and the effects on motor function were assessed. For tryptophan, l -kynurenine, 3-hydroxy-kynurenine, and anthranilic acid, the effects ranged from reversible to irreversible motor dysfunction, to instant paralysis and death. 3-Hydroxy-anthranilic acid could induce a tetanus like spasm of the wings. Tryptophan, 3-hydroxykynurenine, and 3-hydroxy-anthranilic acid were toxic to primary cultures of insect neurons. It is possible that some of these metabolites have a distinct role in larvae during the apoptotic events related to neurometamorphosis. |
Databáze: | OpenAIRE |
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