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Balega M. I., Schneider S. A., Borodach V. A., Tkachenko E. K. Study of the influence of topical application of Persantine on the condition of the oral mucosa of rats under the conditions of systemic action of pathogenic factors. Journal of Education, Health and Sport. 2018;8(9):1778-1784. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1467938 http://ojs.ukw.edu.pl/index.php/johs/article/view/6211 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 17.09.2018. Revised: 24.09.2018. Accepted: 27.09.2018. Study of the influence of topical application of Persantine on the condition of the oral mucosa of rats under the conditions of systemic action of pathogenic factors 1M. I. Balega, Ph.D.; 2S. A. Schneider, Dr.Sc.; 1V. A. Borodach, Ph.D.; 2E. K. Tkachenko, Ph.D. 1Uzhgorod National University, Ukraine 2State Establishment “The Institute of Stomatology and Maxillo-Facial Surgery National Academy of Medical Science of Ukraine” Аbstract Purpose of the study. The study of the protective role of the рersantine when topically applied to the condition of the oral mucosa of rats under conditions of systemic exposure to the fluorine toxicant against the background of polyphenolic insufficiency. Materials and methods. The experiment was conducted on 21 white rat-male 2 months ages that were distributed over 7 animals in a group. The 1st group is intact, the rats were fed on the vivarium diet. In the second group (control oh) in rat bespolifenolnogo background ration was prepared 5 times in week 5% fluorouracil solution per os at a dose of 12.5 mg / kg body weight of rats. The third group, under the combined effect of fluorouracil under the conditions of a bespolyphenol regimen, received topically as a part of a gel, рersantine in a dose of 0.5 mg / kg 5 times a week. Gel - freshly prepared 7.5% potato starch was applied topically to the oral mucosa of the rats. Results and conclusions. introduced against the background of the genotoxicant of fluorouracil in the alimentary deficiency of plant components , manifested in the oral mucosa antioxidant and anti-inflammatory effects. Under the influence of the chimes, the state of the vessels of the microvasculature was normalized due to a significant decrease in edema - the packing density of the vessels and the coefficient of preservation of their lumen increased. There are data on the effect of various toxicants with a lack of plant food components on the occurrence of dental pathology [3]. Keywords: Curantil, local application, pathogenic factors, oral mucosa, rats. |
