Self-propelled particles that transport cargo through flowing blood and halt hemorrhage
| Autor: | Esther B. Lim, Nathan J. White, Diana Chien, Amir Kazerooni, James R. Baylis, James M. Piret, Ju Hun Yeon, Xu Wang, Alex St. John, Thomas F. Burke, Lindsay S. Machan, Christian J. Kastrup, Max H. Thomson, Jesse Q. Zhang, Anna Lee |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
02 engineering and technology macromolecular substances 01 natural sciences Biomaterials Medicine Microparticle Micromotors Research Articles Hemostatic Agent Self-propelling particles Hemostasis Multidisciplinary Coagulation integumentary system 010405 organic chemistry business.industry Self-propelled particles fungi food and beverages SciAdv r-articles 021001 nanoscience & nanotechnology 0104 chemical sciences Surgery Drug delivery drug delivery Antifibrinolytic 0210 nano-technology business Calcium carbonate Tranexamic acid Foaming Bubble propulsion Biomedical engineering Uncontrolled bleeding medicine.drug Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Simple, water-reactive particles can carry enzymes upstream through aqueous solutions and into wounds to halt severe bleeding. Delivering therapeutics deep into damaged tissue during bleeding is challenging because of the outward flow of blood. When coagulants cannot reach and clot blood at its source, uncontrolled bleeding can occur and increase surgical complications and fatalities. Self-propelling particles have been proposed as a strategy for transporting agents upstream through blood. Many nanoparticle and microparticle systems exhibiting autonomous or collective movement have been developed, but propulsion has not been used successfully in blood or used in vivo to transport therapeutics. We show that simple gas-generating microparticles consisting of carbonate and tranexamic acid traveled through aqueous solutions at velocities of up to 1.5 cm/s and delivered therapeutics millimeters into the vasculature of wounds. The particles transported themselves through a combination of lateral propulsion, buoyant rise, and convection. When loaded with active thrombin, these particles worked effectively as a hemostatic agent and halted severe hemorrhage in multiple animal models of intraoperative and traumatic bleeding. Many medical applications have been suggested for self-propelling particles, and the findings of this study show that the active self-fueled transport of particles can function in vivo to enhance drug delivery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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