Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination
| Autor: | Kosmas Tsakiridis, Wolfgang Hohenforst-Schmidt, Sofia Baka, Chriforos Kosmidis, Ioannis Boukovinas, Savvas Petanidis, Bojan Zaric, Vladimir Stojsic, Vagelis Christakidis, Paul Zarogoulidis, Haidong Huang, Tatjana Sarcev, Christos Tolis, Anastasios Vagionas, Daliborka Bursac, Konstantinos Sapalidis, Dimitris Petridis, Eleni-Isidora Perdikouri, Biljana Kukic, Konstantinos Romanidis, Tomi Kovacevic, Chrysanthi Sardeli |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology medicine.medical_specialty Lung Neoplasms Standardized uptake value B7-H1 Antigen Metastasis 03 medical and health sciences 0302 clinical medicine Bronchoscopy Carcinoma Non-Small-Cell Lung Internal medicine Biopsy medicine Humans Immunology and Allergy 030212 general & internal medicine Lung cancer Endoscopic Ultrasound-Guided Fine Needle Aspiration PET-CT Lung medicine.diagnostic_test business.industry Public Health Environmental and Occupational Health Prognosis medicine.disease medicine.anatomical_structure 030228 respiratory system Adenocarcinoma Female business |
| Zdroj: | Expert Review of Respiratory Medicine. 15:675-679 |
| ISSN: | 1747-6356 1747-6348 |
| DOI: | 10.1080/17476348.2021.1859373 |
| Popis: | Objectives Lung cancer is still diagnosed at advanced stage and early treatment initiation is needed. Therefore, we need biomarkers or clusters of information that can provide early treatment prognosis. Methods Biopsies were acquired from 471 patients-lung masses with CT-guided biopsy, convex probe transthorasic biopsy and EBUS-TBNA convex probe with 18G needles and 19G needles. Results Standardized uptake value (SUV) measurement is associated with female, smoking status, hepatic metastasis, adenocarcinoma and programmed death-ligand 1 (PD-L1). In specific we expect that SUV ≥ 7 is associated with PD-L1 ≥ 50. Conclusions Lung masses indifferent of size that have SUV ≥ 7 will also have PD-L1 expression ≥ 50. Also, it is likely that these patients will be female with intense smoking habit and hepar or multiple metastasis. |
| Databáze: | OpenAIRE |
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