Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma
| Autor: | Françoise Galateau-Sallé, Elodie Manié, Céline Lecomte, Jessica Zucman-Rossi, Aurélien de Reyniès, Pascal Andujar, Jocelyne Fleury-Feith, Marc-Henri Stern, Annie Renier, Marie-Claude Jaurand, Didier Jean, Emilie Thomas, Marco Giovannini |
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| Přispěvatelé: | Genomique Fonctionnelle des Tumeurs Solides, Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -IFR105-Université Paris Diderot - Paris 7 ( UPD7 ), Université Paris Descartes - Paris 5 ( UPD5 ), Ligue Nationale Contre le Cancer - Paris, Ligue Nationnale Contre le Cancer, Unité de génétique et biologie des cancers ( U830 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut Curie-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire d'Ecotoxicologie - Milieux Aquatiques ( LEMA ), Université Le Havre Normandie ( ULH ), Normandie Université ( NU ) -Normandie Université ( NU ), Institut Mondor de Recherche Biomédicale ( IMRB ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Pneumologie et Pathologie Professionnelle, CHI Créteil, Laboratoire d'histologie et de biologie tumorale, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Tenon [APHP], Cancers et Populations : Facteurs de Risque, Depistage, Pratiques Diagnostiques et Therapeutiques, Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service d'anatomie pathologique, House Ear Institute, Center for Neural Tumor Research, Ligue Nationale Contre le Cancer: CIT1 and CIT2 programs (CIT: Carte d'Identité des Tumeurs), Ministère de l'Emploi, de la Solidarité n°1D004C, de l'Environnement n°AC008B, Ligue Nationale Contre le Cancer (comité de l'Oise, France), Agence Nationale de la Recherche 05 9 31/ANR 05 and Agence Française de Sécurité Sanitaire de l'Environnement et du Travail RD-2004-015., Agence Nationale de la Recherche 05 9 31/ANR 05,Agence Nationale de la Recherche 05 9 31/ANR 05, Génomique Fonctionnelle des Tumeurs Solides (U1162), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Ligue Nationale Contre le Cancer (LNCC), Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Ecotoxicologie - Milieux Aquatiques (LEMA), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Agence Nationale de la Recherche 05 9 31/ANR 05 |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Genome instability
Male Mesothelioma MESH : Mesothelioma MESH : Pleural Neoplasms MESH : Aged MESH : Gene Deletion Mouse models [ SDV.CAN ] Life Sciences [q-bio]/Cancer Pathogenesis Mice 0302 clinical medicine CDKN2A CDKN2B Chromosomes Human array CGH MESH : Mineral Fibers MESH: Animals MESH : Female MESH : Comparative Genomic Hybridization MESH: Genetic Association Studies MESH: Aged 0303 health sciences Comparative Genomic Hybridization Genome MESH: Middle Aged MESH : Asbestos MESH: Genomic Instability MESH: Genomics Mineral fibers Regular Article MESH: Synteny Genomics Middle Aged 3. Good health MESH : Microarray Analysis MESH: Models Animal [ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] 030220 oncology & carcinogenesis MESH: Asbestos Female MESH : Mutation MESH: Xenograft Model Antitumor Assays MESH: Mutation Pleural Neoplasms MESH : Male [SDV.CAN]Life Sciences [q-bio]/Cancer Biology MESH : Xenograft Model Antitumor Assays MESH: Chromosomes Human Synteny Genomic Instability MESH: Pleural Neoplasms Pathology and Forensic Medicine MESH: Mineral Fibers 03 medical and health sciences [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] MESH : Mice medicine Animals Humans MESH: Genome MESH : Middle Aged Allele MESH: Mice Alleles Genetic Association Studies 030304 developmental biology Aged MESH: Humans MESH: Mesothelioma MESH: Alleles MESH : Genomics MESH : Humans MESH : Synteny Asbestos MESH : Genetic Association Studies medicine.disease Molecular biology Xenograft Model Antitumor Assays MESH: Male MESH : Models Animal MESH : Chromosomes Human MESH: Comparative Genomic Hybridization MESH: Microarray Analysis MESH: Gene Deletion Mutation MESH : Animals MESH : Genome MESH : Alleles Chromosome 22 MESH: Female MESH : Genomic Instability Gene Deletion Comparative genomic hybridization |
| Zdroj: | American Journal of Pathology American Journal of Pathology, American Society for Investigative Pathology, 2011, 178 (2), pp.881-94. 〈10.1016/j.ajpath.2010.10.039〉 American Journal of Pathology, American Society for Investigative Pathology, 2011, 178 (2), pp.881-94. ⟨10.1016/j.ajpath.2010.10.039⟩ |
| ISSN: | 0002-9440 1525-2191 |
| DOI: | 10.1016/j.ajpath.2010.10.039〉 |
| Popis: | International audience; Malignant mesothelioma (MM) is an aggressive tumor with a poor prognosis mainly linked to past asbestos exposure. Murine models of MM based on fiber exposure have been developed to elucidate the mechanism of mesothelioma formation. Genomic alterations in murine MM have now been partially characterized. To gain insight into the pathophysiology of mesothelioma, 16 murine and 35 human mesotheliomas were characterized by array-comparative genomic hybridization and were screened for common genomic alterations. Alteration of the 9p21 human region, often by biallelic deletion, was the most frequent alteration in both species, in agreement with the CDKN2A/CDKN2B locus deletion in human disease and murine models. Other shared aberrations were losses of 1p36.3-p35 and 13q14-q33 and gains of 5p15.3-p13 regions. However, some differences were noted, such as absence of recurrent alterations in mouse regions corresponding to human chromosome 22. Comparison between altered recurrent regions in asbestos-exposed and non-asbestos-exposed patients showed a significant difference in the 14q11.2-q21 region, which was also lost in fiber-induced murine mesothelioma. A correlation was also demonstrated between genomic instability and tumorigenicity of human mesothelioma xenografts in nude mice. Overall, these data show similarities between murine and human disease, and contribute to the understanding of the influence of fibers in the pathogenesis of mesothelioma and validation of the murine model for preclinical testing. |
| Databáze: | OpenAIRE |
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