A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease
| Autor: | Dong Wei, Mei-Yue Song, Bolun Li, Jingyu Chen, Ting Shu, Chen Wang, Zhaoguo Li, Ying Liu, Junling Pang, Zhujie Cao, Jing Wang, Baicun Li, Xianmei Qi |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Health Toxicology and Mutagenesis Pulmonary Fibrosis Silicosis 0211 other engineering and technologies Inflammation 02 engineering and technology Disease 010501 environmental sciences 01 natural sciences Fibrosis Pulmonary fibrosis medicine Animals Humans Stage (cooking) Lung 0105 earth and related environmental sciences 021110 strategic defence & security studies business.industry Public Health Environmental and Occupational Health General Medicine Pneumonia medicine.disease Silicon Dioxide Pollution Pathophysiology medicine.anatomical_structure medicine.symptom business |
| Zdroj: | Ecotoxicology and environmental safety. 202 |
| ISSN: | 1090-2414 |
| Popis: | Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological process of silicosis has not been well studied. Here, we defined the progression of silicosis as four stages by unsupervised clustering analysis: normal stage, inflammatory stage, progressive stage and fibrotic stage. Specifically, in normal stage, the lung function was normal, and no inflammation or fibrosis was detected in the lung tissue. Inflammatory stage showed a remarkable pulmonary inflammation but mild fibrosis and lung dysfunction. In progressive stage, significant lung dysfunction was observed, while pulmonary inflammation and fibrosis continued to deteriorate. Fibrotic stage revealed the most severe pulmonary fibrosis and lung dysfunction but no significant deterioration in inflammation. Since the common features were founded in both silicosis patients and rodents, we speculated that the pathophysiological processes of silicosis in patients might be similar to the rodents. Collectively, our new classification identified the process of silicosis, clarified the pathophysiological features of each stage, and provided some new insights for the progression of the disease. |
| Databáze: | OpenAIRE |
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