| Autor: |
Takayuki Imai, Kazuki Nakamura, Sinkichi Morita, Kohsei Hasegawa, Takahiro Goto, Yukio Katori, Yukinori Asada |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Japanese journal of clinical oncology. |
| ISSN: |
1465-3621 |
| Popis: |
BackgroundThe outcome of head and neck cancer has improved in recent years but survival is not yet satisfactory. Interleukin (IL)-6 is a representative inflammatory cytokine and inducer of systemic inflammatory response. It is not known whether preoperative serum level of IL-6 is a prognostic factor in head and neck cancer surgery.MethodsWe studied 181 consecutive patients who underwent head and neck surgery with free tissue transfer reconstruction (HNS-FTTR) between September 2016 and December 2020. Whether preoperative serum IL-6 level was a prognostic risk factor was retrospectively investigated by univariate and multivariate analyses. We also investigated the association between preoperative IL-6 level and representative systemic inflammatory response markers.ResultsThe preoperative IL-6 ≥ 8 pg/mL group had a significantly worse prognosis than the preoperative IL-6 ConclusionsPreoperative serum IL-6 level is an independent poor prognostic factor for both OS and DSS after HNS-FTTR, reflecting the degree of preoperative systemic inflammatory response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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