Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system
| Autor: | Alexander A. Velumian, Jae Young Lee, Min Joung Kim, Pei M. Aui, Michael G. Fehlings, Lijun Li, Steven Petratos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Central Nervous System Cell Adhesion Molecules Neuronal Science Central nervous system Biology Article 03 medical and health sciences Mice 0302 clinical medicine Nogo Receptor 1 Ranvier's Nodes medicine Animals Spinal cord injury Mice Knockout Multidisciplinary Multiple sclerosis Saltatory conduction Experimental autoimmune encephalomyelitis medicine.disease Axons Cell biology Electrophysiology 030104 developmental biology medicine.anatomical_structure Immunology Ultrastructure Medicine 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune encephalomyelitis (EAE). Here we have identified that adult ngr1−/− mice, previously used in EAE and spinal cord injury experiments, display elongated paranodes, and nodes of Ranvier. Unstructured paranodal regions in ngr1−/− mice are matched with more distributed expression pattern of Caspr. Compound action potentials of optic nerves and spinal cords from naïve ngr1−/− mice are delayed and reduced. Molecular interaction studies revealed enhanced Caspr cleavage. Our data suggest that NgR1 may regulate axo-myelin ultrastructure through Caspr-mediated adhesion, regulating the electrophysiological signature of myelinated axons of central nervous system (CNS). |
| Databáze: | OpenAIRE |
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