Cytisine-like alkaloids from Ormosia hosiei Hemsl.E.H. Wilson
| Autor: | Isabelle Pouny, Sirong Yi, Muriel Batut, Laure Vendier, François Sautel, Bruno David, Georges Massiot, Paola B. Arimondo |
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| Přispěvatelé: | Pharmacochimie de la Régulation Epigénétique du Cancer (ETaC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-PIERRE FABRE, Laboratoire de chimie de coordination (LCC), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Pierre FABRE (INSTITUT DE RECHERCHE PIERRE FABRE), Centre de Recherche Pierre Fabre (Centre de R&D Pierre Fabre), PIERRE FABRE-PIERRE FABRE, Chongqing Institute of Medicinal Plant Cultivation, China Academy of Chinese Medical Sciences |
| Rok vydání: | 2014 |
| Předmět: |
Stereochemistry
Molecular Conformation Plant Science Horticulture Ormosia hosiei Receptors Nicotinic Crystallography X-Ray Biochemistry Plant Roots chemistry.chemical_compound Cytisine Alkaloids [CHIM.COOR]Chemical Sciences/Coordination chemistry Molecular Biology Nuclear Magnetic Resonance Biomolecular Octane biology Molecular Structure Plant Stems Chemistry Absolute configuration Fabaceae General Medicine biology.organism_classification Azocines Nicotinic agonist Alpha-4 beta-2 nicotinic receptor Quinolizines |
| Zdroj: | Phytochemistry Phytochemistry, 2014, 107, pp.97-101. ⟨10.1016/j.phytochem.2014.07.022⟩ |
| ISSN: | 1873-3700 |
| Popis: | International audience; Four alkaloids named hosieines A–D were isolated from the root and stem of Ormosia hosiei. Their flat structures were established by mass spectrometry and by a combination of NMR experiments. These molecules probably share a common biosynthetic origin with the lupin alkaloids but they differ in the formation of the last ring, being here part of a rare 2-azabicyclo[3.2.1]octane system. Their absolute configuration was determined by X-ray crystallography using CuKα radiation. As has been described for cytisine, they display a remarkable affinity towards neuronal nicotinic acetylcholine α4β2 receptor. |
| Databáze: | OpenAIRE |
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