Pain sensitivity and thermal detection thresholds in young adults born preterm with very low birth weight or small for gestational age at term compared with controls
| Autor: | Martin Uglem, Trond Sand, Marite Rygg, Johanne Marie Iversen, Marit S. Indredavik, Pål Richard Romundstad, Kristian Bernhard Nilsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pain Threshold Pediatrics medicine.medical_specialty Birth weight medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Pressure Humans Infant Very Low Birth Weight Medicine 030212 general & internal medicine Young adult Mechanical ventilation business.industry Quantitative sensory testing Temperature Chronic pain medicine.disease Low birth weight Anesthesiology and Pain Medicine Neurology Infant Small for Gestational Age Small for gestational age Female Self Report Neurology (clinical) Chronic Pain medicine.symptom business Infant Premature 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Pain |
| Popis: | The objective of this prospective long-term follow-up study was to investigate whether somatosensory function is altered among young adults born preterm with very low birth weight (VLBW; ≤1,500 g) or small for gestational age (SGA;10th percentile) at term. In a blinded quantitative sensory testing protocol, we determined thermal detection, thermal pain, and pressure pain thresholds and the response to prolonged supra-threshold heat among 51 VLBW, 66 term SGA, and 86 term-born controls (birth weight ≥10th percentile) at 28 years. Self-reported chronic pain was also investigated. Except for increased sensitivity to cool in the term SGA group versus controls, we found no significant group differences regarding thermal or pain thresholds. Overall, male participants had higher pain thresholds, and no significant interactions of group and sex were observed (P.14). Within the VLBW group, neonatal mechanical ventilation was associated with reduced sensitivity to cool, and length of mechanical ventilation correlated with lower pressure pain thresholds. The response to prolonged supra-threshold heat was similar between the groups, and the prevalence of self-reported chronic pain was not reliably different. In conclusion, low birth weight young adults were as sensitive to thermal and pain stimuli as term-born, normal birth weight controls, with the same sex differences.To our knowledge, this is the first report on thermal and pain sensitivity among young adults born preterm with VLBW or SGA at term. The negative results from a comprehensive quantitative sensory testing protocol oppose previous findings of altered sensory perception among children and adolescents born preterm. |
| Databáze: | OpenAIRE |
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