Patterns in the prevalence of hepatitis C virus infection at the start of hemodialysis in Japan

Autor: Nami Matsuda, Keiko Uchida, Orie Sugi, Aya Eguchi, Shigeharu Uchida, Takashi Akiba, Naoki Kimata, Yukari Asamiya, Naoko Miwa, Shigeru Otsubo, Kosaku Nitta, Norisato Ikebe, Yuko Iwasa, Tomihito Iwasaki, Keitaro Sato, Kan Kikuchi
Rok vydání: 2008
Předmět:
Zdroj: Clinical and Experimental Nephrology. 12:53-57
ISSN: 1437-7799
1342-1751
Popis: Although hepatitis C virus (HCV) infection is a persistent public health concern in hemodialysis patients, there seem to have been only a few reports on the prevalence of HCV at the start of hemodialysis. In this study we investigated whether patients starting on hemodialysis therapy are positive for anti-HCV antibody or not. The 400 patients who began regular hemodialysis between February 2003 and June 2007 were enrolled in this study. Clinical data such as age, anti-HCV antibody and primary cause of end-stage kidney disease (ESKD) were examined. As healthy controls we used 70,717 healthy blood donors in 2005 whose data were obtained from Tokyo Metropolitan Red Cross Blood Center. Anti-HCV antibody was used as an indicator of HCV infection. Since the prevalence of HCV infection is affected by age in Japan, we classified the patients by age group. The anti-HCV antibody prevalence rate among the patients who were new to hemodialysis was 7.3%, as opposed to 0.15% in the healthy volunteers. The prevalence of HCV in the 31–45-, 46–60-, and 61-year-old groups was significantly higher among the hemodialysis patients than among the healthy volunteers (P = 0.0209
Databáze: OpenAIRE
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