Effect of Mercuhydrin Alone and in Conjunction with Ammonium Chloride On Radiostrontium Excretion in Man
| Autor: | Joseph Samachson, Jacob Menczel, Herta Spencer |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
medicine.medical_specialty Organomercury Compounds Urinary system chemistry.chemical_element Diuresis Urine Calcium Ammonium Chloride General Biochemistry Genetics and Molecular Biology Excretion Strontium Isotopes chemistry.chemical_compound Oral administration Internal medicine medicine Humans Aged Drug Synergism Middle Aged Urinary calcium Endocrinology chemistry Female Ammonium chloride |
| Zdroj: | Experimental Biology and Medicine. 124:1110-1116 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-124-31938 |
| Popis: | SummaryThe diuresis induced by intramuscular injections of mercuhydrin at varying time intervals following intravenous or oral administration of Sr85 was associated with an inconsistent and only slight increase in urinary Sr85 excretion despite a concomitant increase in urinary calcium excretion. Following the discontinuation of mercuhydrin there was marked inhibition of the urinary excretion of Sr85 and calcium. Further increase in urine volume induced by mercuhydrin used in conjunction with ammonium chloride resulted in a marked increase in urinary calcium but not in further enhancement of Sr85 excretion. Mercuhydrin actually diminished the effect of ammonium chloride by inhibiting radiostrontium excretion following discontinuation of this combined therapy. This rebound inhibition of Sr85 excretion contrasts with the sustained increase in Sr85 and calcium excretion following the discontinuation of ammonium chloride. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|