Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation
| Autor: | Jean Soulier, Philippe Bertheau, Mariana Varna, Hideyuki Murata, Christophe Leboeuf, Philippe Ratajczak, Eliane Gluckman, Jean-Michel Cayuela, Allison Desveaux, Luc Legrès, Anne Janin, Gérard Socié |
|---|---|
| Přispěvatelé: | Ratajczak, Philippe, Service d'anatomo-pathologie [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire central d'hématologie, Service de greffe de moelle osseuse [Saint-Louis], Pathologie et virologie moléculaire (PVM (UMR_7151)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology MESH: Tissue Donors Graft vs Host Disease Transplantation Chimera Biochemistry MESH: Mouth Neoplasms 0302 clinical medicine Medicine MESH: In Situ Hybridization Fluorescence MESH: Bone Marrow Transplantation In Situ Hybridization Fluorescence Bone Marrow Transplantation 0303 health sciences MESH: Carcinoma Squamous Cell Hematology Tissue Donors 3. Good health Haematopoiesis medicine.anatomical_structure MESH: Young Adult Child Preschool 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Mouth Neoplasms Stem cell MESH: Transplantation Chimera Adult medicine.medical_specialty Allogeneic transplantation Immunology MESH: Graft vs Host Disease [SDV.CAN]Life Sciences [q-bio]/Cancer Young Adult 03 medical and health sciences Sex Factors [SDV.CAN] Life Sciences [q-bio]/Cancer MESH: Sex Factors MESH: Transplantation Homologous Humans Transplantation Homologous 030304 developmental biology MESH: Humans business.industry Mesenchymal stem cell MESH: Child Preschool MESH: Adult Cell Biology medicine.disease MESH: Male Transplantation Graft-versus-host disease Bone marrow business MESH: Female |
| Zdroj: | Blood Blood, 2009, 113 (8), pp.1834-40. ⟨10.1182/blood-2008-07-171702⟩ Blood, American Society of Hematology, 2009, 113 (8), pp.1834-40. ⟨10.1182/blood-2008-07-171702⟩ |
| ISSN: | 0006-4971 1528-0020 |
| DOI: | 10.1182/blood-2008-07-171702⟩ |
| Popis: | In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some controversies. Only transplantation experiments using genetically distinct recipients and donors can unequivocally show these changes in cell fate. We have analyzed oral squamous cell carcinomas arising in 8 long-term survivors of allogeneic bone marrow transplantation, in whom chronic graft-versus-host disease greatly favors development of squamous cell carcinomas, possibly as a consequence of lichenoid mucosal inflammation. With the use of 2 independent methods, (1) combined immunostaining and fluorescent in situ hybridization (FISH) analysis for X and Y chromosomes sequences in sex-mismatched grafts and (2) comparison of microsatellite typing of laser-microdissected tumor, donor, and recipient cells, in all tumors, we showed that 4 of these 8 epithelial tumors actually arose from the engrafted allogeneic bone marrow. Thus, donor-derived bone marrow cells, whether hematopoietic or mesenchymal, recruited to sites of chronic mucosal inflammation yielded epithelial tumors. Our observations therefore show that marrow cells in humans have a major role in epithelial cancer formation after allogeneic transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|