Regional chromosomal localization of the human gene for galactose-1-phosphate uridyltransferase
Autor: | N. C. Sun, Ernest H. Y. Chu, C. R. Y. Sun |
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Rok vydání: | 1977 |
Předmět: |
Male
UDPglucose-Hexose-1-Phosphate Uridylyltransferase Acid Phosphatase Hybrid Cells Chinese hamster Malate Dehydrogenase Cricetinae Genetics Animals Humans Lymphocytes Gene Genetics (clinical) Synteny biology Acid phosphatase Chromosomes Human 1-3 Chromosome Chromosome Mapping Malate dehydrogenase 1 biology.organism_classification Molecular biology Nucleotidyltransferases Human genetics Somatic fusion Genes Mutation biology.protein |
Zdroj: | Human genetics. 37(3) |
ISSN: | 0340-6717 |
Popis: | Summary. In the progeny of somatic cell hybrids formed by fusion of human lymphocytes and Chinese hamster mutant cells, a single human chromosome A2 was selectively retained when grown in appropriate medium. Spontaneous breakage of this chromosome in different hybrid subclones led to the assignment of the gene for galactose-l-phosphate uridyltransferase to the centromeric region of this chromosome (2qll-2q14). This gene is shown to be syntenic to the previously mapped genes for acid phosphatase 1 and malate dehydrogenase 1. |
Databáze: | OpenAIRE |
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