Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy
| Autor: | J. F. Fraumeni, L.E. Beane Freeman, Rochelle E. Curtis, Graça M. Dores, William F. Anderson |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Neoplasms Radiation-Induced Adolescent Short Communication medicine.medical_treatment Breast Neoplasms Breast cancer Risk Factors immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans Survivors Risk factor skin and connective tissue diseases second breast cancer Aged Aged 80 and over Hodgkin's lymphoma Radiotherapy business.industry Cancer Neoplasms Second Primary Middle Aged radiation-related breast cancer medicine.disease Hodgkin Disease humanities Lymphoma Surgery Radiation therapy Female Histopathology Breast disease business SEER Program |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6605877 |
| Popis: | Background: It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC. Methods: Using population-based data, we calculated BC risk following HL according to clinicopathologic features. Results: Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81–6.35) and nine-fold (95% CI=6.93–12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC. Conclusion: Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors. |
| Databáze: | OpenAIRE |
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