Bisphosphonate-Conjugated Photo-Crosslinking Polyanionic Hyaluronic Acid Microbeads for Controlled BMP2 Delivery and Enhanced Bone Formation Efficacy
| Autor: | Min-Kyoung Kim, Jung Joo Kim, Hong-Phuong Nguyen, Su-Geun Yang, Ratchapol Jenjob, Yixin Jiang |
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| Rok vydání: | 2021 |
| Předmět: |
animal structures
Polymers and Plastics medicine.medical_treatment Bone Morphogenetic Protein 2 Bioengineering Conjugated system Bone morphogenetic protein 2 Biomaterials chemistry.chemical_compound Osteogenesis Hyaluronic acid Photo crosslinking Materials Chemistry medicine Animals Bone formation Hyaluronic Acid Diphosphonates fungi Cationic polymerization Bisphosphonate biological factors Microspheres Rats chemistry Spinal fusion embryonic structures Biophysics |
| Zdroj: | Biomacromolecules. 22(10) |
| ISSN: | 1526-4602 |
| Popis: | In this study, we designed bisphosphonate-conjugated polyanionic hyaluronic acid (HA) microbeads (MBs) for the controlled delivery of bone morphogenetic protein 2 (BMP2). MBs were prepared via the photo-crosslinking of bisphosphonate (alendronate)-conjugated methacrylated HA (Alen-MHA). The polyanionic Alen-MHA MBs actively absorbed cationic BMP2 up to 91.0% of the loading efficacy and displayed a sustained release of BMP2 for 10 days. BMP2/Alen-MHA MBs induced osteogenic-related genes in cellular experiments and showed the highly increased bone formation efficacy in thigh muscle injection and rat spinal fusion animal models. Thus, BMP2/Alen-MHA MBs provide a promising opportunity to improve the delivery efficiency of BMP2. |
| Databáze: | OpenAIRE |
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