Alleviation of Tinnitus With High-Frequency Stimulation of the Dorsal Cochlear Nucleus
| Autor: | Marlieke L. van Erp, Robert J. Stokroos, Marcus L.F. Janssen, Ali Jahanshahi, Jasper V. Smit, Gusta van Zwieten, Yasin Temel |
|---|---|
| Přispěvatelé: | Promovendi MHN, KNO, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Med Staf Spec Neurochirurgie (9), Neurochirurgie, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), Klinische Neurowetenschappen, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA AIOS Keel Neus Oorheelkunde (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Inferior colliculus
Male Startle response Reflex Startle Auditory Pathways Tinnitus/physiopathology medicine.medical_treatment HYPERACTIVITY Evoked Potentials Auditory Brain Stem/physiology Rats Sprague-Dawley 0302 clinical medicine Premovement neuronal activity Evoked Potentials Auditory Prepulse inhibition Brain Stem/physiology HEARING 0303 health sciences c-Fos medicine.diagnostic_test integumentary system Startle ACOUSTIC-TRAUMA STEM lcsh:Otorhinolaryngology lcsh:RF1-547 deep brain stimulation medicine.anatomical_structure GPIAS Cochlear Nucleus/physiopathology medicine.symptom DEEP BRAIN-STIMULATION Dorsal cochlear nucleus Cochlear Nucleus Deep brain stimulation dorsal cochlear nucleus Auditory cortex 03 medical and health sciences Speech and Hearing Deep Brain Stimulation/methods Reflex medicine Evoked Potentials Auditory Brain Stem otorhinolaryngologic diseases Journal Article Animals tinnitus 030304 developmental biology SUPPRESSION Auditory Pathways/physiopathology business.industry Animal INFERIOR COLLICULUS ELECTRICAL-STIMULATION Rats Disease Models Animal Otorhinolaryngology Disease Models Innovations in Tinnitus Research: Original Article BLAST-INDUCED TINNITUS Sprague-Dawley business Noise Neuroscience 030217 neurology & neurosurgery Tinnitus AUDITORY-CORTEX |
| Zdroj: | Trends in Hearing, 23, 1 Trends in Hearing, Vol 23 (2019) Trends in hearing, 23:2331216519835080, 1-10. SAGE Publications Inc. Trends in Hearing |
| ISSN: | 2331-2165 |
| DOI: | 10.1177/2331216519835080 |
| Popis: | Deep brain stimulation of the central auditory pathway is emerging as a promising treatment modality for tinnitus. Within this pathway, the dorsal cochlear nucleus (DCN) plays a key role in the pathophysiology of tinnitus and is believed to be a tinnitus generator. We hypothesized that high-frequency stimulation (HFS) of the DCN would influence tinnitus-related abnormal neuronal activity within the auditory pathway and hereby suppress tinnitus. To this end, we assessed the effect of HFS of the DCN in a noise-induced rat model of tinnitus. The presence of tinnitus was verified using the gap prepulse inhibition of the acoustic startle response paradigm. Hearing thresholds were determined before and after noise trauma by measuring the auditory brainstem responses. In addition, changes in neuronal activity induced by noise trauma and HFS were assessed using c-Fos immunohistochemistry in related structures. Results showed tinnitus development after noise trauma and hearing loss ipsilateral to the side exposed to noise trauma. During HFS of the DCN, tinnitus was suppressed. There was no change in c-Fos expression within the central auditory pathway after HFS. These findings suggest that DCN-HFS changes patterns of activity and results in information lesioning within the network and hereby blocking the relay of abnormal tinnitus-related neuronal activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|