Influence of intracerebroventricular or intraperitoneal administration of cannabinoid receptor agonist (WIN 55,212-2) and inverse agonist (AM 251) on the regulation of food intake and hypothalamic serotonin levels
| Autor: | María López-Jurado, Hanaa Hoddah, Gloria Urbano, Mohammed Errami, Juan Llopis, Pilar Aranda, Ikram Merroun, Jesús M. Porres |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Agonist Serotonin medicine.medical_specialty Cannabinoid receptor medicine.drug_class Microdialysis Morpholines medicine.medical_treatment Hypothalamus Gene Expression Medicine (miscellaneous) Motor Activity Naphthalenes Cerebral Ventricles Eating Random Allocation chemistry.chemical_compound Piperidines Internal medicine medicine Animals Inverse agonist Rats Wistar Neurotransmitter WIN 55 212-2 Chromatography High Pressure Liquid Cannabinoid Receptor Agonists Nutrition and Dietetics Dose-Response Relationship Drug digestive oral and skin physiology Genes fos Extracellular Fluid Hydroxyindoleacetic Acid Benzoxazines Rats Dose–response relationship Endocrinology chemistry Pyrazoles Cannabinoid Injections Intraperitoneal medicine.drug |
| Zdroj: | British Journal of Nutrition. 101:1569 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114508083530 |
| Popis: | The effect of intracerebroventricular or intraperitoneal administration of cannabinoid receptor agonist WIN 55,212-2 or inverse agonist AM 251 on food intake and extracellular levels of serotonin and acetic acid 5-hydroxy-indol from presatiated rats was studied. Compared to the vehicle-injected control, the intracerebroventricular administration of WIN 55,212-2 was associated with a significant increase in food intake, whereas the administration of AM 251 caused a significant reduction in this respect. These results were accompanied by considerable reductions or increases in serotonin and acetic acid 5-hydroxy-indol levels compared to the vehicle-injected control and the baseline values for the different experimental groups studied. Intraperitoneal administration of WIN 55,212-2 at doses of 1 and 2 mg/kg promoted hyperphagia up to 6 h after injection, whereas administration of a higher dose (5 mg/kg) significantly inhibited food intake and motor behaviour in partially satiated rats. Administration of any of the AM 251 doses studied (0.5, 1, 2, 5 mg/kg) led to a significant decrease in the amount of food ingested from 2 h after the injection, compared to the vehicle-injected control group, with the most striking effect being observed when the 5 mg/kg dose was injected. |
| Databáze: | OpenAIRE |
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