Loss of regional bone mineral density in the first 12 months following renal transplantation
| Autor: | M.K. Almond, J. Cunningham, Kenneth R. Evans, J. T. C. Kwan |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Time Factors Bone disease medicine.medical_treatment Absorptiometry Photon Bone Density Risk Factors medicine Humans Osteodystrophy Femur Dual-energy X-ray absorptiometry Femoral neck Aged Bone mineral medicine.diagnostic_test business.industry Immunosuppression Middle Aged musculoskeletal system medicine.disease Kidney Transplantation Spine Surgery Osteopenia Transplantation Bone Diseases Metabolic medicine.anatomical_structure Parathyroid Hormone Female business |
| Zdroj: | Nephron. 66(1) |
| ISSN: | 1660-8151 |
| Popis: | A high incidence of osteopenia is likely in renal transplant recipients in whom pre-existing uraemic osteodystrophy, persisting hyperparathyroidism and glucocorticoids constitute a formidable array of risk factors. The correction of some biochemical and hormonal abnormalities, an increase in body weight and an increase in physical activity following transplantation could favour improvements in skeletal integrity. Using dual energy X-ray absorptiometry (DEXA), we studied prospectively the regional bone mineral density (BMD) of 34 consecutive cadaveric renal allograft recipients who were already established on dialysis. BMD of these patients was measured at the time of transplantation and was repeated at 3, 6 and 12 months following the transplantation. Immunosuppression was achieved using triple therapy: azathioprine, cyclosporin-A and prednisolone. At baseline, total BMD and BMD at the lumbar spine and femoral neck did not differ from age- and sex-matched controls. Females experienced marked and progressive bone loss at the lumbar spine, with less marked changes at the femoral neck. Males, in contrast, experienced substantial reduction of BMD at the femoral neck at 6 months and a recovery at 12 months without significant change at the lumbar spine. Whole body bone mineral content fell transiently in males, with partial recovery by 6 months. No significant correlation was found with the cumulative doses of either corticosteroids or cyclosporin-A, the duration of hospitalisation, the function of the transplant, patient age or menopausal status.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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